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Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors.
Thornton CD, Fielding S, Karbowniczek K, Roig-Merino A, Burrows AE, FitzPatrick LM, Sharaireh A, Tite JP, Mole SE, Harbottle RP, Caproni LJ, McKay TR. Thornton CD, et al. Among authors: harbottle rp. Mol Ther Methods Clin Dev. 2021 Oct 5;23:348-358. doi: 10.1016/j.omtm.2021.09.018. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34729381 Free PMC article.
An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny.
Roig-Merino A, Urban M, Bozza M, Peterson JD, Bullen L, Büchler-Schäff M, Stäble S, van der Hoeven F, Müller-Decker K, McKay TR, Milsom MD, Harbottle RP. Roig-Merino A, et al. Among authors: harbottle rp. Stem Cell Reports. 2022 Jan 11;17(1):143-158. doi: 10.1016/j.stemcr.2021.11.011. Epub 2021 Dec 22. Stem Cell Reports. 2022. PMID: 34942088 Free PMC article.
Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection.
Chan T, Grisch-Chan HM, Schmierer P, Subotic U, Rimann N, Scherer T, Hetzel U, Bozza M, Harbottle R, Williams JA, Steblaj B, Ringer SK, Häberle J, Sidler X, Thöny B. Chan T, et al. Mol Ther Methods Clin Dev. 2022 Jan 19;24:268-279. doi: 10.1016/j.omtm.2022.01.006. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35211639 Free PMC article.
Sustained expression from DNA vectors.
Wong SP, Argyros O, Harbottle RP. Wong SP, et al. Among authors: harbottle rp. Adv Genet. 2015;89:113-152. doi: 10.1016/bs.adgen.2014.11.002. Epub 2014 Dec 18. Adv Genet. 2015. PMID: 25620010 Review.
Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.
Hart SL, Arancibia-Cárcamo CV, Wolfert MA, Mailhos C, O'Reilly NJ, Ali RR, Coutelle C, George AJ, Harbottle RP, Knight AM, Larkin DF, Levinsky RJ, Seymour LW, Thrasher AJ, Kinnon C. Hart SL, et al. Among authors: harbottle rp. Hum Gene Ther. 1998 Mar 1;9(4):575-85. doi: 10.1089/hum.1998.9.4-575. Hum Gene Ther. 1998. PMID: 9525318
54 results