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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions.
Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi C, Roth G, Baudoin JP, Ansaldi C, Decaens T, Halfon P. Brun S, et al. Among authors: legouffe r. Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5. Autophagy. 2022. PMID: 34740311 Free PMC article.
Tumor Distribution by Quantitative Mass Spectrometry Imaging of the Inhibitor of Apoptosis Protein Antagonist Xevinapant in Patients with Resectable Squamous Cell Carcinoma of the Head and Neck (EudraCT Number: 2014-004655-31).
Menetrey A, Legouffe R, Haouala A, Bonnel D, Rouits E, Bosq J, Stauber J. Menetrey A, et al. Among authors: legouffe r. Anal Chem. 2022 Sep 13;94(36):12333-12341. doi: 10.1021/acs.analchem.2c00943. Epub 2022 Aug 30. Anal Chem. 2022. PMID: 36040476
A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits.
Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D, Wisztorski M, Salzet M, Laprevote O, Baudouin C. Brignole-Baudouin F, et al. Among authors: legouffe r. PLoS One. 2012;7(11):e50180. doi: 10.1371/journal.pone.0050180. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209668 Free PMC article.
MALDI-TOF MS imaging of controlled release implants.
Kreye F, Hamm G, Karrout Y, Legouffe R, Bonnel D, Siepmann F, Siepmann J. Kreye F, et al. Among authors: legouffe r. J Control Release. 2012 Jul 10;161(1):98-108. doi: 10.1016/j.jconrel.2012.04.017. Epub 2012 Apr 19. J Control Release. 2012. PMID: 22551600
Topical Bimiralisib Shows Meaningful Cutaneous Drug Levels in Healthy Volunteers and Mycosis Fungoides Patients but No Clinical Activity in a First-in-Human, Randomized Controlled Trial.
Wind SS, Jansen MAA, Rijsbergen M, van Esdonk MJ, Ziagkos D, Cheng WC, Niemeyer-van der Kolk T, Korsten J, Gruszka A, Schmitz-Rohmer D, Bonnel D, Legouffe R, Barré F, Bekkenk MW, de Haas ERM, Quint KD, Rolli M, Streefkerk HJ, Burggraaf J, Vermeer MH, Rissmann R. Wind SS, et al. Among authors: legouffe r. Cancers (Basel). 2022 Mar 15;14(6):1510. doi: 10.3390/cancers14061510. Cancers (Basel). 2022. PMID: 35326659 Free PMC article.
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