Kang S - Search Results

1

Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.

Yoon NG, Lee H, Kim SY, Hu S, Kim D, Yang S, Hong KB, Lee JH, Kang S, Kim BG, Myung K, Lee C, Kang BH. Yoon NG, et al. Among authors: kang s, kang bh. J Am Chem Soc. 2021 Dec 1;143(47):19684-19696. doi: 10.1021/jacs.1c07099. Epub 2021 Nov 10. J Am Chem Soc. 2021. PMID: 34758612

2

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.

Park HK, Jeong H, Ko E, Lee G, Lee JE, Lee SK, Lee AJ, Im JY, Hu S, Kim SH, Lee JH, Lee C, Kang S, Kang BH. Park HK, et al. Among authors: kang s, kang bh. J Med Chem. 2017 Sep 14;60(17):7569-7578. doi: 10.1021/acs.jmedchem.7b00978. Epub 2017 Aug 30. J Med Chem. 2017. PMID: 28816449

3

CF₃-Substituted Mollugin 2-(4-Morpholinyl)-ethyl ester as a Potential Anti-inflammatory Agent with Improved Aqueous Solubility and Metabolic Stability.

Hong KB, Kim D, Kim BK, Woo SY, Lee JH, Han SH, Bae GU, Kang S. Hong KB, et al. Among authors: kang s. Molecules. 2018 Aug 14;23(8):2030. doi: 10.3390/molecules23082030. Molecules. 2018. PMID: 30110934 Free PMC article.

4

Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.

Jung S, Yoon NG, Yang S, Kim D, Lee WS, Hong KB, Lee C, Kang BH, Lee JH, Kang S. Jung S, et al. Among authors: kang s, kang bh. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126809. doi: 10.1016/j.bmcl.2019.126809. Epub 2019 Nov 11. Bioorg Med Chem Lett. 2020. PMID: 31839539

5

Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.

Kim D, Kim SY, Kim D, Yoon NG, Yun J, Hong KB, Lee C, Lee JH, Kang BH, Kang S. Kim D, et al. Among authors: kang s, kang bh. Bioorg Chem. 2020 Aug;101:103901. doi: 10.1016/j.bioorg.2020.103901. Epub 2020 Jun 15. Bioorg Chem. 2020. PMID: 32590225

6

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors.

Park E, Lee SJ, Moon H, Park J, Jeon H, Hwang JS, Hwang H, Hong KB, Han SH, Choi S, Kang S. Park E, et al. Among authors: kang s. J Med Chem. 2021 Jan 28;64(2):958-979. doi: 10.1021/acs.jmedchem.0c01026. Epub 2021 Jan 11. J Med Chem. 2021. PMID: 33428419

7

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.

Yang S, Yoon NG, Kim D, Park E, Kim SY, Lee JH, Lee C, Kang BH, Kang S. Yang S, et al. Among authors: kang s, kang bh. ACS Med Chem Lett. 2021 Jun 16;12(7):1173-1180. doi: 10.1021/acsmedchemlett.1c00213. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267888 Free PMC article.

8

Correction to "Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site".

Yoon NG, Lee H, Kim SY, Hu S, Kim D, Yang S, Hong KB, Lee JH, Kang S, Kim BG, Myung K, Lee C, Kang BH. Yoon NG, et al. Among authors: kang s, kang bh. J Am Chem Soc. 2022 Feb 2;144(4):2020. doi: 10.1021/jacs.2c00039. Epub 2022 Jan 19. J Am Chem Soc. 2022. PMID: 35044746 No abstract available.

9

Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity.

Yang S, Yoon NG, Park MA, Yun J, Im JY, Kang BH, Kang S. Yang S, et al. Among authors: kang s, kang bh. Bioorg Chem. 2022 Sep;126:105856. doi: 10.1016/j.bioorg.2022.105856. Epub 2022 May 20. Bioorg Chem. 2022. PMID: 35661618

10

2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.

Park E, Song KH, Kim D, Lee M, Van Manh N, Kim H, Hong KB, Lee J, Song JY, Kang S. Park E, et al. Among authors: kang s. ACS Med Chem Lett. 2022 Aug 16;13(9):1459-1467. doi: 10.1021/acsmedchemlett.2c00256. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105338 Free PMC article.

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