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Page 1
In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain.
Subramanian G, Duclos B, Johnson PD, Williams T, Ross JT, Bowen SJ, Zhu Y, White JA, Hedke C, Huczek D, Collard W, Javens C, Vairagoundar R, Respondek T, Zachary T, Maddux T, Cox MR, Kamerling S, Gonzales AJ. Subramanian G, et al. Among authors: bowen sj. ACS Med Chem Lett. 2021 Oct 25;12(11):1847-1852. doi: 10.1021/acsmedchemlett.1c00483. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795875 Free PMC article.
Lead identification and characterization of hTrkA type 2 inhibitors.
Subramanian G, Zhu Y, Bowen SJ, Roush N, White JA, Huczek D, Zachary T, Javens C, Williams T, Janssen A, Gonzales A. Subramanian G, et al. Among authors: bowen sj. Bioorg Med Chem Lett. 2019 Nov 15;29(22):126680. doi: 10.1016/j.bmcl.2019.126680. Epub 2019 Sep 13. Bioorg Med Chem Lett. 2019. PMID: 31610943
Synthetic inhibitor leads of human tropomyosin receptor kinase A (hTrkA).
Subramanian G, Vairagoundar R, Bowen SJ, Roush N, Zachary T, Javens C, Williams T, Janssen A, Gonzales A. Subramanian G, et al. Among authors: bowen sj. RSC Med Chem. 2020 Jan 10;11(3):370-377. doi: 10.1039/c9md00554d. eCollection 2020 Mar 1. RSC Med Chem. 2020. PMID: 33479642 Free PMC article.
Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
Subramanian G, Bowen SJ, Zhu Y, Roush N, Zachary T, Javens C, Williams T, Janssen A, Gonzales A. Subramanian G, et al. Among authors: bowen sj. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126624. doi: 10.1016/j.bmcl.2019.126624. Epub 2019 Aug 16. Bioorg Med Chem Lett. 2019. PMID: 31444087
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.
Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Schweitzer BA, Wilcox MV, McDonald J, Smith SE, Foltin S, Rumsey J, Yang YS, Walker MC, Kamtekar S, Beidler D, Thorarensen A. Meyers MJ, et al. Among authors: bowen sj. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53. doi: 10.1016/j.bmcl.2011.08.048. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21924613
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds.
Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Walker MC, Schweitzer BA, Madsen HM, Tenbrink RE, McDonald J, Smith SE, Foltin S, Beidler D, Thorarensen A. Meyers MJ, et al. Among authors: bowen sj. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44. doi: 10.1016/j.bmcl.2011.08.055. Epub 2011 Aug 22. Bioorg Med Chem Lett. 2011. PMID: 21924614
Structure based design of novel irreversible FAAH inhibitors.
Wang JL, Bowen SJ, Schweitzer BA, Madsen HM, McDonald J, Pelc MJ, Tenbrink RE, Beidler D, Thorarensen A. Wang JL, et al. Among authors: bowen sj. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5970-4. doi: 10.1016/j.bmcl.2009.07.101. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19765986
24 results