Heitman J - Search Results

1

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.

Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Gobeil SM, et al. Among authors: heitman j. mBio. 2021 Dec 21;12(6):e0300021. doi: 10.1128/mBio.03000-21. Epub 2021 Nov 23. mBio. 2021. PMID: 34809463 Free PMC article.

2

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

Breuder T, Hemenway CS, Movva NR, Cardenas ME, Heitman J. Breuder T, et al. Among authors: heitman j. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5372-6. doi: 10.1073/pnas.91.12.5372. Proc Natl Acad Sci U S A. 1994. PMID: 7515500 Free PMC article.

3

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.

Odom A, Del Poeta M, Perfect J, Heitman J. Odom A, et al. Among authors: heitman j. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61. doi: 10.1128/AAC.41.1.156. Antimicrob Agents Chemother. 1997. PMID: 8980772 Free PMC article.

4

Calcineurin is required for virulence of Cryptococcus neoformans.

Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J. Odom A, et al. Among authors: heitman j. EMBO J. 1997 May 15;16(10):2576-89. doi: 10.1093/emboj/16.10.2576. EMBO J. 1997. PMID: 9184205 Free PMC article.

5

Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.

Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VF, Movva NR, Perfect JR, Cardenas ME, Heitman J. Cruz MC, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2000 Jan;44(1):143-9. doi: 10.1128/AAC.44.1.143-149.2000. Antimicrob Agents Chemother. 2000. PMID: 10602736 Free PMC article.

6

Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.

Del Poeta M, Cruz MC, Cardenas ME, Perfect JR, Heitman J. Del Poeta M, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2000 Mar;44(3):739-46. doi: 10.1128/AAC.44.3.739-746.2000. Antimicrob Agents Chemother. 2000. PMID: 10681348 Free PMC article.

7

Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.

Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J. Fox DS, et al. Among authors: heitman j. Mol Microbiol. 2001 Feb;39(4):835-49. doi: 10.1046/j.1365-2958.2001.02295.x. Mol Microbiol. 2001. PMID: 11251806 Free article.

8

Calcineurin is essential for survival during membrane stress in Candida albicans.

Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, Perfect JR, McCusker JH, Heitman J. Cruz MC, et al. Among authors: heitman j. EMBO J. 2002 Feb 15;21(4):546-59. doi: 10.1093/emboj/21.4.546. EMBO J. 2002. PMID: 11847103 Free PMC article.

9

Good fungi gone bad: the corruption of calcineurin.

Fox DS, Heitman J. Fox DS, et al. Among authors: heitman j. Bioessays. 2002 Oct;24(10):894-903. doi: 10.1002/bies.10157. Bioessays. 2002. PMID: 12325122 Review.

10

Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.

Blankenship JR, Steinbach WJ, Perfect JR, Heitman J. Blankenship JR, et al. Among authors: heitman j. Curr Opin Investig Drugs. 2003 Feb;4(2):192-9. Curr Opin Investig Drugs. 2003. PMID: 12669381 Review.

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