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An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies.
Findlay A, Turner C, Schilter H, Deodhar M, Zhou W, Perryman L, Foot J, Zahoor A, Yao Y, Hamilton R, Brock M, Raso C, Stolp J, Galati M, Hamprecht D, Charlton B, Jarolimek W. Findlay A, et al. Among authors: hamprecht d. Clin Transl Med. 2021 Nov;11(11):e572. doi: 10.1002/ctm2.572. Clin Transl Med. 2021. PMID: 34841699 Free PMC article. No abstract available.
PROTACs Targeting MLKL Protect Cells from Necroptosis.
Rathje OH, Perryman L, Payne RJ, Hamprecht DW. Rathje OH, et al. Among authors: hamprecht dw. J Med Chem. 2023 Aug 24;66(16):11216-11236. doi: 10.1021/acs.jmedchem.3c00665. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535857
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy.
Zimmermann T, Thomas L, Baader-Pagler T, Haebel P, Simon E, Reindl W, Bajrami B, Rist W, Uphues I, Drucker DJ, Klein H, Santhanam R, Hamprecht D, Neubauer H, Augustin R. Zimmermann T, et al. Among authors: hamprecht d. Mol Metab. 2022 Dec;66:101633. doi: 10.1016/j.molmet.2022.101633. Epub 2022 Nov 7. Mol Metab. 2022. PMID: 36356832 Free PMC article.
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP. Holmes IP, et al. Among authors: hamprecht d. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2013-6. doi: 10.1016/j.bmcl.2010.01.090. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20153647
1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists.
Micheli F, Arista L, Bonanomi G, Blaney FE, Braggio S, Capelli AM, Checchia A, Damiani F, Di-Fabio R, Fontana S, Gentile G, Griffante C, Hamprecht D, Marchioro C, Mugnaini M, Piner J, Ratti E, Tedesco G, Tarsi L, Terreni S, Worby A, Ashby CR Jr, Heidbreder C. Micheli F, et al. Among authors: hamprecht d. J Med Chem. 2010 Jan 14;53(1):374-91. doi: 10.1021/jm901319p. J Med Chem. 2010. PMID: 19891474
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