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Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization.
Khedkar NR, Irlapatti NR, Dadke D, Kanoje V, Shaikh Z, Karche V, Shinde V, Deshmukh G, Patil A, Jachak S, Phukan S, Kizhakinagath PA, Gholve M, Bhankhede T, Daler J, Nemade HN, Budhe S, Pareek H, Yeshodharan R, Gupta R, Kalia A, Pandey D, Wagh A, Kumar S, Patil V, Modi D, Sharma N, Ahirrao P, Mehta M, Kumar H, Nigade P, Tamane K, Mallurwar S, Kuldharan S, Pawar S, Vishwase G, Bokan S, Singh M, Naik K, Ingawale S, Shankar R, Kamalakannan P, Venugopal S, George SK, Padiya KJ, Nemmani KVS, Gundu J, Bhonde M, Narasimham L, Sindkhedkar M, Shah C, Sinha N, Sharma S, Bakhle D, Kamboj RK, Palle VP. Khedkar NR, et al. Among authors: vishwase g. J Med Chem. 2021 Dec 9;64(23):17004-17030. doi: 10.1021/acs.jmedchem.1c01403. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843241
Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.
Kanoje V, Pandey D, Wagh A, Patra S, Kumar Marisetti A, Reddy M, Samant C, Mahajan N, Gholve M, Sabde S, Trivedi S, Bhankhede T, Patil V, Nigade P, Modi D, Mehta M, Ahirrao P, Tota S, Nanda B, Pawar S, Polawar A, Tamane K, Kuldharan S, Vishwase G, Jana N, Mahangare SJ, Vidhate P, Lagad D, Gundu J, Phukan S, Shukla M, Narasimham L, Nemmani KVS, Bhonde M, Sharma S, Kamboj RK, Palle VP. Kanoje V, et al. Among authors: vishwase g. Eur J Pharmacol. 2022 Jul 15;927:175054. doi: 10.1016/j.ejphar.2022.175054. Epub 2022 May 27. Eur J Pharmacol. 2022. PMID: 35636524