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ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.
Baker AT, Boyd RJ, Sarkar D, Teijeira-Crespo A, Chan CK, Bates E, Waraich K, Vant J, Wilson E, Truong CD, Lipka-Lloyd M, Fromme P, Vermaas J, Williams D, Machiesky L, Heurich M, Nagalo BM, Coughlan L, Umlauf S, Chiu PL, Rizkallah PJ, Cohen TS, Parker AL, Singharoy A, Borad MJ. Baker AT, et al. Among authors: coughlan l. Sci Adv. 2021 Dec 3;7(49):eabl8213. doi: 10.1126/sciadv.abl8213. Epub 2021 Dec 1. Sci Adv. 2021. PMID: 34851659 Free PMC article.
A chimeric haemagglutinin-based universal influenza virus vaccine boosts human cellular immune responses directed towards the conserved haemagglutinin stalk domain and the viral nucleoprotein.
Bliss CM, Nachbagauer R, Mariottini C, Cuevas F, Feser J, Naficy A, Bernstein DI, Guptill J, Walter EB, Berlanda-Scorza F, Innis BL, García-Sastre A, Palese P, Krammer F, Coughlan L. Bliss CM, et al. Among authors: coughlan l. EBioMedicine. 2024 Jun;104:105153. doi: 10.1016/j.ebiom.2024.105153. Epub 2024 May 27. EBioMedicine. 2024. PMID: 38805853 Free PMC article. Clinical Trial.
A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications.
Bliss CM, Hulin-Curtis SL, Williams M, Marušková M, Davies JA, Statkute E, Baker AT, Stack L, Kerstetter L, Kerr-Jones LE, Milward KF, Russell G, George SJ, Badder LM, Stanton RJ, Coughlan L, Humphreys IR, Parker AL. Bliss CM, et al. Among authors: coughlan l. Mol Ther Methods Clin Dev. 2024 Jul 30;32(3):101308. doi: 10.1016/j.omtm.2024.101308. eCollection 2024 Sep 12. Mol Ther Methods Clin Dev. 2024. PMID: 39206304 Free PMC article.
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
Alba R, Bradshaw AC, Coughlan L, Denby L, McDonald RA, Waddington SN, Buckley SM, Greig JA, Parker AL, Miller AM, Wang H, Lieber A, van Rooijen N, McVey JH, Nicklin SA, Baker AH. Alba R, et al. Among authors: coughlan l. Blood. 2010 Oct 14;116(15):2656-64. doi: 10.1182/blood-2009-12-260026. Epub 2010 Jul 7. Blood. 2010. PMID: 20610817 Free PMC article.
81 results