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Page 1
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. Wang SB, et al. Among authors: ambati m. Sci Immunol. 2021 Dec 3;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 3. Sci Immunol. 2021. PMID: 34860583 Free PMC article.
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. Kerur N, et al. Among authors: ambati k, ambati j, ambati m, ambati vl. Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27. Nat Med. 2018. PMID: 29176737 Free PMC article.
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
Ambati J, Magagnoli J, Leung H, Wang SB, Andrews CA, Fu D, Pandey A, Sahu S, Narendran S, Hirahara S, Fukuda S, Sun J, Pandya L, Ambati M, Pereira F, Varshney A, Cummings T, Hardin JW, Edun B, Bennett CL, Ambati K, Fowler BJ, Kerur N, Röver C, Leitinger N, Werner BC, Stein JD, Sutton SS, Gelfand BD. Ambati J, et al. Among authors: ambati k, ambati m. Nat Commun. 2020 Sep 23;11(1):4737. doi: 10.1038/s41467-020-18528-z. Nat Commun. 2020. PMID: 32968070 Free PMC article.
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. Fukuda S, et al. Among authors: ambati k, ambati j, ambati m, ambati vl. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2022751118. doi: 10.1073/pnas.2022751118. Proc Natl Acad Sci U S A. 2021. PMID: 33526699 Free PMC article.
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J. Narendran S, et al. Among authors: ambati k, ambati j, ambati m, ambati vl. Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z. Signal Transduct Target Ther. 2021. PMID: 33850097 Free PMC article.
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J. Fukuda S, et al. Among authors: ambati m. Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29. Sci Adv. 2021. PMID: 34586848 Free PMC article.
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
Ambati M, Apicella I, Wang SB, Narendran S, Leung H, Pereira F, Nagasaka Y, Huang P, Varshney A, Baker KL, Marion KM, Shadmehr M, Stains CI, Werner BC, Sadda SR, Taylor EW, Sutton SS, Magagnoli J, Gelfand BD. Ambati M, et al. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2102975118. doi: 10.1073/pnas.2102975118. Proc Natl Acad Sci U S A. 2021. PMID: 34620711 Free PMC article.
A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration.
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Varshney A, Baker KL, Marion KM, Ambati M, Ambati VL, Ambati K, Sadda SR, Gelfand BD, Ambati J. Narendran S, et al. Among authors: ambati k, ambati j, ambati m, ambati vl. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):4. doi: 10.1167/iovs.61.10.4. Invest Ophthalmol Vis Sci. 2020. PMID: 32749462 Free PMC article.
Precision Medicine in Periodontics: A Literature Review.
Gundelly M, Pusuluri SV, Koduganti RR, Ambati M, Chiluveru S, Chandaka M. Gundelly M, et al. Among authors: ambati m. Cureus. 2024 Sep 8;16(9):e68952. doi: 10.7759/cureus.68952. eCollection 2024 Sep. Cureus. 2024. PMID: 39385855 Free PMC article. Review.
Efficacy of root coverage with the use of the conventional versus laser-assisted flap technique with platelet-rich fibrin in class I and class II gingival recession: A randomized clinical trial.
Bommala M, Koduganti RR, Panthula VR, Jammula SP, Gireddy H, Ambati M, Ganachari B. Bommala M, et al. Among authors: ambati m. Dent Med Probl. 2023 Oct-Dec;60(4):583-592. doi: 10.17219/dmp/150887. Dent Med Probl. 2023. PMID: 38133989 Free article. Clinical Trial.
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