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JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice.
Rivellini C, Porrello E, Dina G, Mrakic-Sposta S, Vezzoli A, Bacigaluppi M, Gullotta GS, Chaabane L, Leocani L, Marenna S, Colombo E, Farina C, Newcombe J, Nave KA, Pardi R, Quattrini A, Previtali SC. Rivellini C, et al. Among authors: newcombe j. J Clin Invest. 2022 Feb 1;132(3):e145071. doi: 10.1172/JCI145071. J Clin Invest. 2022. PMID: 34874913 Free PMC article.
Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.
Colombo E, Triolo D, Bassani C, Bedogni F, Di Dario M, Dina G, Fredrickx E, Fermo I, Martinelli V, Newcombe J, Taveggia C, Quattrini A, Comi G, Farina C. Colombo E, et al. Among authors: newcombe j. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2025804118. doi: 10.1073/pnas.2025804118. Proc Natl Acad Sci U S A. 2021. PMID: 34183414 Free PMC article.
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus JM, Shi J, Heckman MG, Spiegel MR, Cook C, Song Y, Yue M, Daughrity LM, Carlomagno Y, Jansen-West K, de Castro CF, DeTure M, Koga S, Wang YC, Sivakumar P, Bodo C, Candalija A, Talbot K, Selvaraj BT, Burr K, Chandran S, Newcombe J, Lashley T, Hubbard I, Catalano D, Kim D, Propp N, Fennessey S; NYGC ALS Consortium; Fagegaltier D, Phatnani H, Secrier M, Fisher EM, Oskarsson B, van Blitterswijk M, Rademakers R, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Josephs KA, Thompson EA, Raj T, Ward M, Dickson DW, Gendron TF, Fratta P, Petrucelli L. Prudencio M, et al. Among authors: newcombe j. J Clin Invest. 2020 Nov 2;130(11):6080-6092. doi: 10.1172/JCI139741. J Clin Invest. 2020. PMID: 32790644 Free PMC article.
CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.
Krumbholz M, Theil D, Steinmeyer F, Cepok S, Hemmer B, Hofbauer M, Farina C, Derfuss T, Junker A, Arzberger T, Sinicina I, Hartle C, Newcombe J, Hohlfeld R, Meinl E. Krumbholz M, et al. Among authors: newcombe j. J Neuroimmunol. 2007 Oct;190(1-2):72-9. doi: 10.1016/j.jneuroim.2007.07.024. Epub 2007 Sep 6. J Neuroimmunol. 2007. PMID: 17825430
249 results