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Page 1
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis.
Slamova I, Adib R, Ellmerich S, Golos MR, Gilbertson JA, Botcher N, Canetti D, Taylor GW, Rendell N, Tennent GA, Verona G, Porcari R, Mangione PP, Gillmore JD, Pepys MB, Bellotti V, Hawkins PN, Al-Shawi R, Simons JP. Slamova I, et al. Among authors: porcari r. Nat Commun. 2021 Dec 7;12(1):7112. doi: 10.1038/s41467-021-27416-z. Nat Commun. 2021. PMID: 34876572 Free PMC article.
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Mangione PP, Porcari R, Gillmore JD, Pucci P, Monti M, Porcari M, Giorgetti S, Marchese L, Raimondi S, Serpell LC, Chen W, Relini A, Marcoux J, Clatworthy IR, Taylor GW, Tennent GA, Robinson CV, Hawkins PN, Stoppini M, Wood SP, Pepys MB, Bellotti V. Mangione PP, et al. Among authors: porcari m, porcari r. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1539-44. doi: 10.1073/pnas.1317488111. Epub 2014 Jan 13. Proc Natl Acad Sci U S A. 2014. PMID: 24474780 Free PMC article.
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.
Marcoux J, Mangione PP, Porcari R, Degiacomi MT, Verona G, Taylor GW, Giorgetti S, Raimondi S, Sanglier-Cianférani S, Benesch JL, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Stoppini M, Robinson CV, Pepys MB, Bellotti V. Marcoux J, et al. Among authors: porcari r. EMBO Mol Med. 2015 Oct;7(10):1337-49. doi: 10.15252/emmm.201505357. EMBO Mol Med. 2015. PMID: 26286619 Free PMC article.
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
Valleix S, Verona G, Jourde-Chiche N, Nédelec B, Mangione PP, Bridoux F, Mangé A, Dogan A, Goujon JM, Lhomme M, Dauteuille C, Chabert M, Porcari R, Waudby CA, Relini A, Talmud PJ, Kovrov O, Olivecrona G, Stoppini M, Christodoulou J, Hawkins PN, Grateau G, Delpech M, Kontush A, Gillmore JD, Kalopissis AD, Bellotti V. Valleix S, et al. Among authors: porcari r. Nat Commun. 2016 Jan 21;7:10353. doi: 10.1038/ncomms10353. Nat Commun. 2016. PMID: 26790392 Free PMC article.
Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.
Mangione PP, Esposito G, Relini A, Raimondi S, Porcari R, Giorgetti S, Corazza A, Fogolari F, Penco A, Goto Y, Lee YH, Yagi H, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Chiti F, Rolandi R, Taylor GW, Pepys MB, Stoppini M, Bellotti V. Mangione PP, et al. Among authors: porcari r. J Biol Chem. 2013 Oct 25;288(43):30917-30. doi: 10.1074/jbc.M113.498857. Epub 2013 Sep 6. J Biol Chem. 2013. PMID: 24014031 Free PMC article.
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.
Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V. Raimondi S, et al. Among authors: porcari r. Sci Rep. 2017 Apr 21;7:46711. doi: 10.1038/srep46711. Sci Rep. 2017. PMID: 28429761 Free PMC article.
23 results