Cai H - Search Results

1

Nonclinical toxicology development of a novel antibody antibiotic conjugate for treating invasive Staphylococcus Aureus infections.

Stagg NJ, Katavolos P, Achilles Poon K, Zhong S, Ljumanovic N, Kamath A, Cai H, Carrasco-Triguero M, Halpern W. Stagg NJ, et al. Among authors: cai h. Toxicol Appl Pharmacol. 2022 Jan 15;435:115811. doi: 10.1016/j.taap.2021.115811. Epub 2021 Dec 9. Toxicol Appl Pharmacol. 2022. PMID: 34896194

2

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.

Deng R, Zhou C, Li D, Cai H, Sukumaran S, Carrasco-Triguero M, Saad O, Nazzal D, Lowe C, Ramanujan S, Kamath AV. Deng R, et al. Among authors: cai h. MAbs. 2019 Aug/Sep;11(6):1162-1174. doi: 10.1080/19420862.2019.1627152. Epub 2019 Jun 20. MAbs. 2019. PMID: 31219754 Free PMC article.

3

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging.

Zhou C, Cai H, Baruch A, Lewin-Koh N, Yang M, Guo F, Xu D, Deng R, Hazenbos W, Kamath AV. Zhou C, et al. Among authors: cai h. PLoS One. 2019 Oct 29;14(10):e0224096. doi: 10.1371/journal.pone.0224096. eCollection 2019. PLoS One. 2019. PMID: 31661493 Free PMC article.

4

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.

Cai H, Yip V, Lee MV, Wong S, Saad O, Ma S, Ljumanovic N, Khojasteh SC, Kamath AV, Shen BQ. Cai H, et al. Drug Metab Dispos. 2020 Nov;48(11):1161-1168. doi: 10.1124/dmd.120.000092. Epub 2020 Aug 24. Drug Metab Dispos. 2020. PMID: 32839277

5

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions.

Sun Y, Cai H, Hu Z, Boswell CA, Diao J, Li C, Zhang L, Shen A, Teske CA, Zhang B, Kamath AV, Jiang G. Sun Y, et al. Among authors: cai h. J Pharm Sci. 2020 Dec;109(12):3690-3696. doi: 10.1016/j.xphs.2020.09.003. Epub 2020 Sep 7. J Pharm Sci. 2020. PMID: 32910947

6

A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.

Kakiuchi-Kiyota S, Ross T, Wallweber HA, Kiefer JR, Schutten MM, Adedeji AO, Cai H, Hendricks R, Cohen S, Myneni S, Liu L, Fullerton A, Corr N, Yu L, de Almeida Nagata D, Zhong S, Leong SR, Li J, Nakamura R, Sumiyoshi T, Li J, Ovacik AM, Zheng B, Dillon M, Spiess C, Wingert S, Rajkovic E, Ellwanger K, Reusch U, Polson AG. Kakiuchi-Kiyota S, et al. Among authors: cai h. Leukemia. 2022 Apr;36(4):1006-1014. doi: 10.1038/s41375-021-01478-w. Epub 2022 Jan 10. Leukemia. 2022. PMID: 35001074

7

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma.

Cai H, Kakiuchi-Kiyota S, Hendricks R, Zhong S, Liu L, Adedeji AO, Chan P, Schutten MM, Kamath AV, Ovacik MA. Cai H, et al. AAPS J. 2022 Sep 20;24(6):100. doi: 10.1208/s12248-022-00744-8. AAPS J. 2022. PMID: 36127472

8

Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys.

Cai H, Tao X, Shim J, Bauer RN, Bremer M, Bu W, LaMar J, Basile R, Dere E, Nguyen T, Laing S, Chan P, Yi T, Koerber JT, Sperinde G, Stefanich E. Cai H, et al. AAPS J. 2023 Jun 23;25(4):64. doi: 10.1208/s12248-023-00829-y. AAPS J. 2023. PMID: 37353723

9

Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer.

Lo AA, Johnston J, Li J, Mandikian D, Hristopoulos M, Clark R, Nickles D, Liang WC, Hötzel K, Dunlap D, Pham T, Cai H, Ovacik M, Bravo-Perez D, Mai E, Slaga D, Ellerman D, Ziai J, Totpal K, Lee G, Boswell CA, Payandeh J, Wu Y, Junttila TT. Lo AA, et al. Among authors: cai h. Mol Cancer Ther. 2021 Apr;20(4):716-725. doi: 10.1158/1535-7163.MCT-20-0490. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536191

10

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.

Sadekar SS, Bowen M, Cai H, Jamalian S, Rafidi H, Shatz-Binder W, Lafrance-Vanasse J, Chan P, Meilandt WJ, Oldendorp A, Sreedhara A, Daugherty A, Crowell S, Wildsmith KR, Atwal J, Fuji RN, Horvath J. Sadekar SS, et al. Among authors: cai h. Clin Pharmacol Ther. 2022 Apr;111(4):826-834. doi: 10.1002/cpt.2531. Epub 2022 Feb 23. Clin Pharmacol Ther. 2022. PMID: 35064573 Free PMC article. Review.

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