Sun Y - Search Results

1

Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy.

Li Y, Wang C, Xu T, Pan P, Yu Q, Xu L, Xiong X, Hou T, Cui S, Sun Y. Li Y, et al. Among authors: sun y. Acta Pharm Sin B. 2021 Nov;11(11):3567-3584. doi: 10.1016/j.apsb.2021.07.012. Epub 2021 Jul 17. Acta Pharm Sin B. 2021. PMID: 34900537 Free PMC article.

2

Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target.

Jia L, Yang J, Hao X, Zheng M, He H, Xiong X, Xu L, Sun Y. Jia L, et al. Among authors: sun y. Clin Cancer Res. 2010 Feb 1;16(3):814-24. doi: 10.1158/1078-0432.CCR-09-1592. Epub 2010 Jan 26. Clin Cancer Res. 2010. PMID: 20103673 Free PMC article.

3

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

Zhao Y, Xiong X, Sun Y. Zhao Y, et al. Among authors: sun y. Mol Cell. 2011 Oct 21;44(2):304-16. doi: 10.1016/j.molcel.2011.08.029. Mol Cell. 2011. PMID: 22017876 Free PMC article.

4

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.

Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y. Xiong X, et al. Among authors: sun y. Elife. 2014 Aug 21;3:e02236. doi: 10.7554/eLife.02236. Elife. 2014. PMID: 25144937 Free PMC article.

5

Suramin inhibits cullin-RING E3 ubiquitin ligases.

Wu K, Chong RA, Yu Q, Bai J, Spratt DE, Ching K, Lee C, Miao H, Tappin I, Hurwitz J, Zheng N, Shaw GS, Sun Y, Felsenfeld DP, Sanchez R, Zheng JN, Pan ZQ. Wu K, et al. Among authors: sun y. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8. doi: 10.1073/pnas.1601089113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001857 Free PMC article.

6

The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity.

Xu X, Xiong X, Sun Y. Xu X, et al. Among authors: sun y. Sci China Life Sci. 2016 Jul;59(7):656-72. doi: 10.1007/s11427-016-0018-0. Epub 2016 Jun 13. Sci China Life Sci. 2016. PMID: 27294833 Review.

7

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.

Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y. Xu J, et al. Among authors: sun y. Nat Commun. 2017 Jan 16;8:14002. doi: 10.1038/ncomms14002. Nat Commun. 2017. PMID: 28090088 Free PMC article.

8

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.

Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, Chinnaswamy K, Layton S, Stuckey J, Yu Q, Zhou W, Pan Z, Sun Y, Wang S. Zhou H, et al. Among authors: sun y. Nat Commun. 2017 Oct 27;8(1):1150. doi: 10.1038/s41467-017-01243-7. Nat Commun. 2017. PMID: 29074978 Free PMC article.

9

Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.

Zhao Y, Tan M, Liu X, Xiong X, Sun Y. Zhao Y, et al. Among authors: sun y. Cell Death Dis. 2018 Feb 2;9(2):145. doi: 10.1038/s41419-017-0192-3. Cell Death Dis. 2018. PMID: 29396424 Free PMC article.

10

Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis.

Xiong X, Liu X, Li H, He H, Sun Y, Zhao Y. Xiong X, et al. Among authors: sun y. Cell Death Dis. 2018 Nov 13;9(11):1131. doi: 10.1038/s41419-018-1168-7. Cell Death Dis. 2018. PMID: 30425236 Free PMC article.

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