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A Phase Ib Dose Escalation Trial of RO4929097 (a γ-secretase inhibitor) in Combination with Exemestane in Patients with ER + Metastatic Breast Cancer (MBC).
Means-Powell JA, Mayer IA, Ismail-Khan R, Del Valle L, Tonetti D, Abramson VG, Sanders MS, Lush RM, Sorrentino C, Majumder S, Miele L. Means-Powell JA, et al. Among authors: tonetti d. Clin Breast Cancer. 2022 Feb;22(2):103-114. doi: 10.1016/j.clbc.2021.10.013. Epub 2021 Oct 28. Clin Breast Cancer. 2022. PMID: 34903452 Free PMC article. Clinical Trial.
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.
Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L. Rizzo P, et al. Among authors: tonetti da, d souza g. Cancer Res. 2008 Jul 1;68(13):5226-35. doi: 10.1158/0008-5472.CAN-07-5744. Cancer Res. 2008. PMID: 18593923 Free PMC article.
Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells.
Yun J, Pannuti A, Espinoza I, Zhu H, Hicks C, Zhu X, Caskey M, Rizzo P, D'Souza G, Backus K, Denning MF, Coon J, Sun M, Bresnick EH, Osipo C, Wu J, Strack PR, Tonetti DA, Miele L. Yun J, et al. Among authors: tonetti da, d souza g. Oncogenesis. 2013 Aug 5;2(8):e60. doi: 10.1038/oncsis.2013.26. Oncogenesis. 2013. PMID: 23917222 Free PMC article.
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Andreano KJ, Wardell SE, Baker JG, Desautels TK, Baldi R, Chao CA, Heetderks KA, Bae Y, Xiong R, Tonetti DA, Gutgesell LM, Zhao J, Sorrentino JA, Thompson DA, Bisi JE, Strum JC, Thatcher GRJ, Norris JD. Andreano KJ, et al. Among authors: tonetti da. Breast Cancer Res Treat. 2020 Apr;180(3):635-646. doi: 10.1007/s10549-020-05575-9. Epub 2020 Mar 4. Breast Cancer Res Treat. 2020. PMID: 32130619 Free PMC article.
173 results