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Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.
Bheemanaboina RRY, de Souza ML, Gonzalez ML, Mahmood SU, Eck T, Kreiss T, Aylor SO, Roth A, Lee P, Pybus BS, Colussi DJ, Childers WE, Gordon J, Siekierka JJ, Bhanot P, Rotella DP. Bheemanaboina RRY, et al. Among authors: roth a. ACS Med Chem Lett. 2021 Nov 15;12(12):1962-1967. doi: 10.1021/acsmedchemlett.1c00540. eCollection 2021 Dec 9. ACS Med Chem Lett. 2021. PMID: 34917261 Free PMC article.
Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
Vanachayangkul P, Im-Erbsin R, Tungtaeng A, Kodchakorn C, Roth A, Adams J, Chaisatit C, Saingam P, Sciotti RJ, Reichard GA, Nolan CK, Pybus BS, Black CC, Lugo-Roman LA, Wegner MD, Smith PL, Wojnarski M, Vesely BA, Kobylinski KC. Vanachayangkul P, et al. Among authors: roth a. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00741-20. doi: 10.1128/AAC.00741-20. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32660993 Free PMC article.
The fibrinolytic system enables the onset of Plasmodium infection in the mosquito vector and the mammalian host.
Alves E Silva TL, Radtke A, Balaban A, Pascini TV, Pala ZR, Roth A, Alvarenga PH, Jeong YJ, Olivas J, Ghosh AK, Bui H, Pybus BS, Sinnis P, Jacobs-Lorena M, Vega-Rodríguez J. Alves E Silva TL, et al. Among authors: roth a. Sci Adv. 2021 Feb 5;7(6):eabe3362. doi: 10.1126/sciadv.abe3362. Print 2021 Feb. Sci Adv. 2021. PMID: 33547079 Free PMC article.
Functional human IgA targets a conserved site on malaria sporozoites.
Tan J, Cho H, Pholcharee T, Pereira LS, Doumbo S, Doumtabe D, Flynn BJ, Schön A, Kanatani S, Aylor SO, Oyen D, Vistein R, Wang L, Dillon M, Skinner J, Peterson M, Li S, Idris AH, Molina-Cruz A, Zhao M, Olano LR, Lee PJ, Roth A, Sinnis P, Barillas-Mury C, Kayentao K, Ongoiba A, Francica JR, Traore B, Wilson IA, Seder RA, Crompton PD. Tan J, et al. Among authors: roth a. Sci Transl Med. 2021 Jun 23;13(599):eabg2344. doi: 10.1126/scitranslmed.abg2344. Sci Transl Med. 2021. PMID: 34162751 Free PMC article.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
Kancharla P, Ortiz D, Fargo CM, Zhang X, Li Y, Sanchez M, Kumar A, Yeluguri M, Dodean RA, Caridha D, Madejczyk MS, Martin M, Jin X, Blount C, Chetree R, Pannone K, Dinh HT, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Dennis WE, Roncal N, Pybus BS, Lee PJ, Roth A, Reynolds KA, Kelly JX, Landfear SM. Kancharla P, et al. Among authors: roth a. J Med Chem. 2024 May 23;67(10):8323-8345. doi: 10.1021/acs.jmedchem.4c00517. Epub 2024 May 9. J Med Chem. 2024. PMID: 38722757 Free PMC article.
Optimization of B-Ring-Functionalized Antimalarial Tambjamines and Prodiginines.
Kumar A, Chithanna S, Li Y, Zhang X, Dodean RA, Caridha D, Madejczyk MS, Lee PJ, Jin X, Chetree R, Blount C, Dennis WE, DeLuca J, Vuong C, Pannone K, Dinh HT, Leed S, Roth A, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: roth a. J Med Chem. 2024 Nov 14;67(21):19755-19776. doi: 10.1021/acs.jmedchem.4c02093. Epub 2024 Oct 19. J Med Chem. 2024. PMID: 39425665 Free PMC article.
Tambjamines as Fast-Acting Multistage Antimalarials.
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. Kumar A, et al. Among authors: roth a. ACS Infect Dis. 2024 Dec 13;10(12):4291-4300. doi: 10.1021/acsinfecdis.4c00659. Epub 2024 Nov 11. ACS Infect Dis. 2024. PMID: 39526703 Free PMC article.
Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.
Pottenger AE, Roy D, Srinivasan S, Chavas TEJ, Vlaskin V, Ho DK, Livingston VC, Maktabi M, Lin H, Zhang J, Pybus B, Kudyba K, Roth A, Senter P, Tyson G, Huber HE, Wesche D, Rochford R, Burke PA, Stayton PS. Pottenger AE, et al. Among authors: roth a. Sci Adv. 2024 Apr 19;10(16):eadk4492. doi: 10.1126/sciadv.adk4492. Epub 2024 Apr 19. Sci Adv. 2024. PMID: 38640243 Free PMC article.
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.
Roth A, Maher SP, Conway AJ, Ubalee R, Chaumeau V, Andolina C, Kaba SA, Vantaux A, Bakowski MA, Thomson-Luque R, Adapa SR, Singh N, Barnes SJ, Cooper CA, Rouillier M, McNamara CW, Mikolajczak SA, Sather N, Witkowski B, Campo B, Kappe SHI, Lanar DE, Nosten F, Davidson S, Jiang RHY, Kyle DE, Adams JH. Roth A, et al. Nat Commun. 2018 May 9;9(1):1837. doi: 10.1038/s41467-018-04221-9. Nat Commun. 2018. PMID: 29743474 Free PMC article.
2,434 results