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Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.
Nguyen T, Gamage TF, Finlay DB, Decker AM, Langston TL, Barrus D, Glass M, Li JX, Kenakin TP, Zhang Y. Nguyen T, et al. Among authors: finlay db. J Med Chem. 2022 Jan 13;65(1):257-270. doi: 10.1021/acs.jmedchem.1c01432. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34929081 Free PMC article.
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Soethoudt M, et al. Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958. Nat Commun. 2017. PMID: 28045021 Free PMC article.
An intact model for quantifying functional selectivity.
Zhu X, Finlay DB, Glass M, Duffull SB. Zhu X, et al. Among authors: finlay db. Sci Rep. 2019 Feb 22;9(1):2557. doi: 10.1038/s41598-019-39000-z. Sci Rep. 2019. PMID: 30796256 Free PMC article.
93 results