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The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.
Grajales D, Vázquez P, Ruíz-Rosario M, Tudurí E, Mirasierra M, Ferreira V, Hitos AB, Koller D, Zubiaur P, Cigudosa JC, Abad-Santos F, Vallejo M, Quesada I, Tirosh B, Leibowitz G, Valverde ÁM. Grajales D, et al. Among authors: leibowitz g. Diabetologia. 2022 Mar;65(3):490-505. doi: 10.1007/s00125-021-05630-0. Epub 2021 Dec 21. Diabetologia. 2022. PMID: 34932133 Free PMC article.
Autophagy is a major regulator of beta cell insulin homeostasis.
Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G. Riahi Y, et al. Among authors: leibowitz g. Diabetologia. 2016 Jul;59(7):1480-1491. doi: 10.1007/s00125-016-3868-9. Epub 2016 Jan 30. Diabetologia. 2016. PMID: 26831301 Free PMC article.
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.
Israeli T, Riahi Y, Garzon P, Louzada RA, Werneck-de-Castro JP, Blandino-Rosano M, Yeroslaviz-Stolper R, Kadosh L, Tornovsky-Babeay S, Hacker G, Israeli N, Agmon O, Tirosh B, Cerasi E, Bernal-Mizrachi E, Leibowitz G. Israeli T, et al. Among authors: leibowitz g. Diabetes. 2022 Mar 1;71(3):453-469. doi: 10.2337/db21-0281. Diabetes. 2022. PMID: 34862201 Free PMC article.
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Riahi Y, Kogot-Levin A, Kadosh L, Agranovich B, Malka A, Assa M, Piran R, Avrahami D, Glaser B, Gottlieb E, Jackson F 3rd, Cerasi E, Bernal-Mizrachi E, Helman A, Leibowitz G. Riahi Y, et al. Among authors: leibowitz g. Diabetologia. 2023 Oct;66(10):1925-1942. doi: 10.1007/s00125-023-05967-8. Epub 2023 Jul 22. Diabetologia. 2023. PMID: 37480416
128 results