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ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.
McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D, Bhakta S. McGuigan C, et al. Among authors: mchugh td. Bioorg Med Chem. 2014 May 1;22(9):2816-24. doi: 10.1016/j.bmc.2014.02.056. Epub 2014 Mar 15. Bioorg Med Chem. 2014. PMID: 24690527 Free article.
Improving the tuberculosis drug development pipeline.
Evangelopoulos D, McHugh TD. Evangelopoulos D, et al. Among authors: mchugh td. Chem Biol Drug Des. 2015 Nov;86(5):951-60. doi: 10.1111/cbdd.12549. Epub 2015 Mar 28. Chem Biol Drug Des. 2015. PMID: 25772393 Review.
Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria.
Bhakta S, Scalacci N, Maitra A, Brown AK, Dasugari S, Evangelopoulos D, McHugh TD, Mortazavi PN, Twist A, Petricci E, Manetti F, Castagnolo D. Bhakta S, et al. Among authors: mchugh td. J Med Chem. 2016 Mar 24;59(6):2780-93. doi: 10.1021/acs.jmedchem.6b00031. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26907951 Free article.
Application of the hollow fibre infection model (HFIM) in antimicrobial development: a systematic review and recommendations of reporting.
Sadouki Z, McHugh TD, Aarnoutse R, Ortiz Canseco J, Darlow C, Hope W, van Ingen J, Longshaw C, Manissero D, Mead A, Pelligand L, Phee L, Readman J, Ruth MM, Standing JF, Stone N, Wey EQ, Kloprogge F. Sadouki Z, et al. Among authors: mchugh td. J Antimicrob Chemother. 2021 Aug 12;76(9):2252-2259. doi: 10.1093/jac/dkab160. J Antimicrob Chemother. 2021. PMID: 34179966 Free PMC article.
248 results