Desai AJ - Search Results

1

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol.

Harikumar KG, Coudrat T, Desai AJ, Dong M, Dengler DG, Furness SGB, Christopoulos A, Wootten D, Sergienko EA, Sexton PM, Miller LJ. Harikumar KG, et al. Among authors: desai aj. Front Endocrinol (Lausanne). 2021 Dec 7;12:789957. doi: 10.3389/fendo.2021.789957. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34950108 Free PMC article.

2

Sensitivity of cholecystokinin receptors to membrane cholesterol content.

Desai AJ, Miller LJ. Desai AJ, et al. Front Endocrinol (Lausanne). 2012 Oct 18;3:123. doi: 10.3389/fendo.2012.00123. eCollection 2012. Front Endocrinol (Lausanne). 2012. PMID: 23087674 Free PMC article.

3

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.

Desai AJ, Harikumar KG, Miller LJ. Desai AJ, et al. J Biol Chem. 2014 Jun 27;289(26):18314-26. doi: 10.1074/jbc.M114.570200. Epub 2014 May 13. J Biol Chem. 2014. PMID: 24825903 Free PMC article.

4

Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.

Desai AJ, Henke BR, Miller LJ. Desai AJ, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1849-55. doi: 10.1016/j.bmcl.2015.03.051. Epub 2015 Mar 24. Bioorg Med Chem Lett. 2015. PMID: 25862198 Free PMC article.

5

Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.

Desai AJ, Dong M, Harikumar KG, Miller LJ. Desai AJ, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G377-86. doi: 10.1152/ajpgi.00173.2015. Epub 2015 Jul 2. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26138469 Free PMC article.

6

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.

Desai AJ, Lam PC, Orry A, Abagyan R, Christopoulos A, Sexton PM, Miller LJ. Desai AJ, et al. J Med Chem. 2015 Dec 24;58(24):9562-77. doi: 10.1021/acs.jmedchem.5b01110. Epub 2015 Dec 10. J Med Chem. 2015. PMID: 26654202 Free PMC article.

7

Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol.

Desai AJ, Dong M, Miller LJ. Desai AJ, et al. Clin Nutr. 2016 Dec;35(6):1374-1379. doi: 10.1016/j.clnu.2016.03.003. Epub 2016 Mar 15. Clin Nutr. 2016. PMID: 27016394 Free PMC article.

8

Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target.

Miller LJ, Desai AJ. Miller LJ, et al. Among authors: desai aj. Trends Endocrinol Metab. 2016 Sep;27(9):609-619. doi: 10.1016/j.tem.2016.04.002. Epub 2016 May 4. Trends Endocrinol Metab. 2016. PMID: 27156041 Free PMC article. Review.

9

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

Desai AJ, Dong M, Langlais BT, Dueck AC, Miller LJ. Desai AJ, et al. Am J Clin Nutr. 2017 Aug;106(2):447-456. doi: 10.3945/ajcn.117.156943. Epub 2017 Jun 7. Am J Clin Nutr. 2017. PMID: 28592602 Free PMC article.

10

Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor.

Desai AJ, Dong M, Harikumar KG, Miller LJ. Desai AJ, et al. Int J Obes Suppl. 2016 Dec;6(Suppl 1):S22-S27. doi: 10.1038/ijosup.2016.5. Epub 2016 Nov 16. Int J Obes Suppl. 2016. PMID: 28685026 Free PMC article. Review.

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