Jackson RJ - Search Results

1

APOE4 derived from astrocytes leads to blood-brain barrier impairment.

Jackson RJ, Meltzer JC, Nguyen H, Commins C, Bennett RE, Hudry E, Hyman BT. Jackson RJ, et al. Brain. 2022 Oct 21;145(10):3582-3593. doi: 10.1093/brain/awab478. Brain. 2022. PMID: 34957486 Free PMC article.

2

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.

Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. Jackson RJ, et al. Eur J Neurosci. 2016 Dec;44(12):3056-3066. doi: 10.1111/ejn.13442. Epub 2016 Nov 12. Eur J Neurosci. 2016. PMID: 27748574 Free PMC article.

3

Opposing Roles of apolipoprotein E in aging and neurodegeneration.

Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT. Hudry E, et al. Life Sci Alliance. 2019 Feb 13;2(1):e201900325. doi: 10.26508/lsa.201900325. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30760557 Free PMC article.

4

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.

Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran AC, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM. Litvinchuk A, et al. Among authors: jackson rj. Ann Neurol. 2021 May;89(5):952-966. doi: 10.1002/ana.26043. Epub 2021 Feb 24. Ann Neurol. 2021. PMID: 33550655 Free PMC article.

5

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease.

Serrano-Pozo A, Li Z, Noori A, Nguyen HN, Mezlini A, Li L, Hudry E, Jackson RJ, Hyman BT, Das S. Serrano-Pozo A, et al. Among authors: jackson rj. Nat Aging. 2021 Oct;1(10):919-931. doi: 10.1038/s43587-021-00123-6. Epub 2021 Oct 11. Nat Aging. 2021. PMID: 36199750 Free PMC article.

6

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.

Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuzer J, Morris R, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, Holtzman DM, Haas W, Davidson BL, Hyman BT. Jackson RJ, et al. Mol Ther. 2024 May 1;32(5):1373-1386. doi: 10.1016/j.ymthe.2024.03.024. Epub 2024 Mar 19. Mol Ther. 2024. PMID: 38504517 Free article.

7

Multifaceted roles of APOE in Alzheimer disease.

Jackson RJ, Hyman BT, Serrano-Pozo A. Jackson RJ, et al. Nat Rev Neurol. 2024 Aug;20(8):457-474. doi: 10.1038/s41582-024-00988-2. Epub 2024 Jun 21. Nat Rev Neurol. 2024. PMID: 38906999 Review.

8

Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription.

Jackson RJ, Melloni A, Fykstra DP, Serrano-Pozo A, Shinobu L, Hyman BT. Jackson RJ, et al. Acta Neuropathol Commun. 2024 Aug 14;12(1):132. doi: 10.1186/s40478-024-01844-6. Acta Neuropathol Commun. 2024. PMID: 39138580 Free PMC article.

9

Clusterin accumulates in synapses in Alzheimer's disease and is increased in apolipoprotein E4 carriers.

Jackson RJ, Rose J, Tulloch J, Henstridge C, Smith C, Spires-Jones TL. Jackson RJ, et al. Brain Commun. 2019;1(1):fcz003. doi: 10.1093/braincomms/fcz003. Epub 2019 Jun 24. Brain Commun. 2019. PMID: 31853523 Free PMC article.

10

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease.

Tzioras M, Davies C, Newman A, Jackson R, Spires-Jones T. Tzioras M, et al. Neuropathol Appl Neurobiol. 2019 Jun;45(4):327-346. doi: 10.1111/nan.12529. Epub 2018 Nov 28. Neuropathol Appl Neurobiol. 2019. PMID: 30394574 Free PMC article. Review.

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