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The relationship between the chemistry and biological activity of the bisphosphonates.
Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG. Ebetino FH, et al. Among authors: sun s. Bone. 2011 Jul;49(1):20-33. doi: 10.1016/j.bone.2011.03.774. Epub 2011 Apr 9. Bone. 2011. PMID: 21497677 Review.
Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.
Junankar S, Shay G, Jurczyluk J, Ali N, Down J, Pocock N, Parker A, Nguyen A, Sun S, Kashemirov B, McKenna CE, Croucher PI, Swarbrick A, Weilbaecher K, Phan TG, Rogers MJ. Junankar S, et al. Among authors: sun s. Cancer Discov. 2015 Jan;5(1):35-42. doi: 10.1158/2159-8290.CD-14-0621. Epub 2014 Oct 13. Cancer Discov. 2015. PMID: 25312016 Free PMC article.
Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms.
Sedghizadeh PP, Sun S, Junka AF, Richard E, Sadrerafi K, Mahabady S, Bakhshalian N, Tjokro N, Bartoszewicz M, Oleksy M, Szymczyk P, Lundy MW, Neighbors JD, Russell RG, McKenna CE, Ebetino FH. Sedghizadeh PP, et al. Among authors: sun s. J Med Chem. 2017 Mar 23;60(6):2326-2343. doi: 10.1021/acs.jmedchem.6b01615. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28121436 Free PMC article.
Bisphosphonates for delivering drugs to bone.
Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK Jr, Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell RGG, McKenna CE, Ebetino FH. Sun S, et al. Br J Pharmacol. 2021 May;178(9):2008-2025. doi: 10.1111/bph.15251. Epub 2021 Apr 10. Br J Pharmacol. 2021. PMID: 32876338 Free PMC article. Review.
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