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Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants.
Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Zhang L, et al. Among authors: chan kk, chan m. bioRxiv [Preprint]. 2021 Dec 22:2021.12.21.473668. doi: 10.1101/2021.12.21.473668. bioRxiv. 2021. Update in: Nat Chem Biol. 2022 Mar;18(3):342-351. doi: 10.1038/s41589-021-00965-6 PMID: 34981059 Free PMC article. Updated. Preprint.
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants.
Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. Zhang L, et al. Among authors: chan kk, chan m. Nat Chem Biol. 2022 Mar;18(3):342-351. doi: 10.1038/s41589-021-00965-6. Epub 2022 Jan 19. Nat Chem Biol. 2022. PMID: 35046611 Free PMC article.
An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.
Zhang L, Narayanan KK, Cooper L, Chan KK, Devlin CA, Aguhob A, Shirley K, Rong L, Rehman J, Malik AB, Procko E. Zhang L, et al. Among authors: chan kk. bioRxiv [Preprint]. 2022 Mar 28:2022.03.28.486075. doi: 10.1101/2022.03.28.486075. bioRxiv. 2022. Update in: EMBO Mol Med. 2022 Nov 8;14(11):e16109. doi: 10.15252/emmm.202216109 PMID: 35378764 Free PMC article. Updated. Preprint.
1,184 results