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Page 1
Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, Ommen A, Ma W, Smith ED, Spangenberg AW, Eaves J, Hanson GJ, Hinkley L, Jenks M, Lewis M, Otto J, Pronk GJ, Verleysen K, Haystead TA, Hall SE. Fadden P, et al. Chem Biol. 2010 Jul 30;17(7):686-94. doi: 10.1016/j.chembiol.2010.04.015. Chem Biol. 2010. PMID: 20659681
Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA. Barrott JJ, et al. Among authors: haystead ta. Chem Biol. 2013 Sep 19;20(9):1187-97. doi: 10.1016/j.chembiol.2013.08.004. Epub 2013 Sep 12. Chem Biol. 2013. PMID: 24035283 Free PMC article.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M. Woodford MR, et al. Nat Commun. 2016 Jun 29;7:12037. doi: 10.1038/ncomms12037. Nat Commun. 2016. PMID: 27353360 Free PMC article.
Cellular fatty acid synthase is required for late stages of HIV-1 replication.
Kulkarni MM, Ratcliff AN, Bhat M, Alwarawrah Y, Hughes P, Arcos J, Loiselle D, Torrelles JB, Funderburg NT, Haystead TA, Kwiek JJ. Kulkarni MM, et al. Among authors: haystead ta. Retrovirology. 2017 Sep 29;14(1):45. doi: 10.1186/s12977-017-0368-z. Retrovirology. 2017. PMID: 28962653 Free PMC article.
In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.
Osada T, Kaneko K, Gwin WR, Morse MA, Hobeika A, Pogue BW, Hartman ZC, Hughes PF, Haystead T, Lyerly HK. Osada T, et al. Among authors: haystead t. Clin Cancer Res. 2017 Dec 15;23(24):7531-7542. doi: 10.1158/1078-0432.CCR-17-1453. Epub 2017 Oct 9. Clin Cancer Res. 2017. PMID: 28993342
Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.
Posfai D, Eubanks AL, Keim AI, Lu KY, Wang GZ, Hughes PF, Kato N, Haystead TA, Derbyshire ER. Posfai D, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01799-17. doi: 10.1128/AAC.01799-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29339390 Free PMC article.
Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.
Raphemot R, Eubanks AL, Toro-Moreno M, Geiger RA, Hughes PF, Lu KY, Haystead TAJ, Derbyshire ER. Raphemot R, et al. Cell Chem Biol. 2019 Mar 21;26(3):411-419.e7. doi: 10.1016/j.chembiol.2018.11.003. Epub 2018 Dec 27. Cell Chem Biol. 2019. PMID: 30595530 Free PMC article.
172 results