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Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage.
Sadat SMA, Wuest M, Paiva IM, Munira S, Sarrami N, Sanaee F, Yang X, Paladino M, Binkhathlan Z, Karimi-Busheri F, Martin GR, Jirik FR, Murray D, Gamper AM, Hall DG, Weinfeld M, Lavasanifar A. Sadat SMA, et al. Among authors: jirik fr. Front Oncol. 2021 Dec 23;11:772920. doi: 10.3389/fonc.2021.772920. eCollection 2021. Front Oncol. 2021. PMID: 35004293 Free PMC article.
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.
Sadat SMA, Paiva IM, Shire Z, Sanaee F, Morgan TDR, Paladino M, Karimi-Busheri F, Mani RS, Martin GR, Jirik FR, Hall DG, Weinfeld M, Lavasanifar A. Sadat SMA, et al. Among authors: jirik fr. J Control Release. 2021 Jun 10;334:335-352. doi: 10.1016/j.jconrel.2021.04.034. Epub 2021 Apr 30. J Control Release. 2021. PMID: 33933518 Free article.
Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis.
de Paiva IM, Vakili MR, Soleimani AH, Tabatabaei Dakhili SA, Munira S, Paladino M, Martin G, Jirik FR, Hall DG, Weinfeld M, Lavasanifar A. de Paiva IM, et al. Among authors: jirik fr. Mol Pharm. 2022 Jun 6;19(6):1825-1838. doi: 10.1021/acs.molpharmaceut.1c00918. Epub 2022 Mar 10. Mol Pharm. 2022. PMID: 35271294 Free PMC article.
PNKP is required for maintaining the integrity of progenitor cell populations in adult mice.
Shin W, Alpaugh W, Hallihan LJ, Sinha S, Crowther E, Martin GR, Scheidl-Yee T, Yang X, Yoon G, Goldsmith T, Berger ND, de Almeida LG, Dufour A, Dobrinski I, Weinfeld M, Jirik FR, Biernaskie J. Shin W, et al. Among authors: jirik fr. Life Sci Alliance. 2021 Jul 5;4(9):e202000790. doi: 10.26508/lsa.202000790. Print 2021 Sep. Life Sci Alliance. 2021. PMID: 34226276 Free PMC article.
153 results