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NKG7 Is Required for Optimal Antitumor T-cell Immunity.
Li XY, Corvino D, Nowlan B, Aguilera AR, Ng SS, Braun M, Cillo AR, Bald T, Smyth MJ, Engwerda CR. Li XY, et al. Among authors: cillo ar. Cancer Immunol Res. 2022 Feb;10(2):154-161. doi: 10.1158/2326-6066.CIR-20-0649. Epub 2022 Jan 10. Cancer Immunol Res. 2022. PMID: 35013002
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells.
Somasundaram A, Cillo AR, Lampenfeld C, Workman CJ, Kunning S, Oliveri L, Velez M, Joyce S, Calderon M, Dadey R, Rajasundaram D, Normolle DP, Watkins SC, Herman JG, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Vignali DAA. Somasundaram A, et al. Among authors: cillo ar. Cancer Immunol Res. 2022 Jul 1;10(7):885-899. doi: 10.1158/2326-6066.CIR-20-0736. Cancer Immunol Res. 2022. PMID: 35587532 Free PMC article.
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Andrews LP, et al. Among authors: cillo ar. Sci Immunol. 2020 Jul 17;5(49):eabc2728. doi: 10.1126/sciimmunol.abc2728. Sci Immunol. 2020. PMID: 32680952 Free PMC article.
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL. Kürten CHL, et al. Among authors: cillo ar. Nat Commun. 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. Nat Commun. 2021. PMID: 34921143 Free PMC article.
Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy.
Andrews LP, Cillo AR, Karapetyan L, Kirkwood JM, Workman CJ, Vignali DAA. Andrews LP, et al. Among authors: cillo ar. Clin Cancer Res. 2022 Dec 1;28(23):5030-5039. doi: 10.1158/1078-0432.CCR-21-2390. Clin Cancer Res. 2022. PMID: 35579997 Free PMC article.
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity.
Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, Wherry EJ, Kirkwood JM, Bruno TC, Workman CJ, Vignali DAA. Andrews LP, et al. Among authors: cillo ar. Cell. 2024 Aug 8;187(16):4355-4372.e22. doi: 10.1016/j.cell.2024.07.016. Cell. 2024. PMID: 39121848
47 results