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Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2.
Yang X, Dickmander RJ, Bayati A, Taft-Benz SA, Smith JL, Wells CI, Madden EA, Brown JW, Lenarcic EM, Yount BL Jr, Chang E, Axtman AD, Baric RS, Heise MT, McPherson PS, Moorman NJ, Willson TM. Yang X, et al. Among authors: lenarcic em. bioRxiv [Preprint]. 2022 Jan 26:2022.01.03.474779. doi: 10.1101/2022.01.03.474779. bioRxiv. 2022. Update in: ACS Chem Biol. 2022 Jul 15;17(7):1937-1950. doi: 10.1021/acschembio.2c00378 PMID: 35018375 Free PMC article. Updated. Preprint.
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM. Feng H, et al. Among authors: lenarcic em. Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2. Nat Immunol. 2017. PMID: 28967880 Free PMC article.
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