Du Z - Search Results

1

Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages.

Chang M, Kumar A, Kumar S, Huhn S, Timp W, Betenbaugh M, Du Z. Chang M, et al. Among authors: du z. Biotechnol Bioeng. 2022 Apr;119(4):1062-1076. doi: 10.1002/bit.28036. Epub 2022 Jan 23. Biotechnol Bioeng. 2022. PMID: 35028935

2

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures.

Du Z, Treiber D, McCarter JD, Fomina-Yadlin D, Saleem RA, McCoy RE, Zhang Y, Tharmalingam T, Leith M, Follstad BD, Dell B, Grisim B, Zupke C, Heath C, Morris AE, Reddy P. Du Z, et al. Biotechnol Bioeng. 2015 Jan;112(1):141-55. doi: 10.1002/bit.25332. Epub 2014 Sep 2. Biotechnol Bioeng. 2015. PMID: 25042542 Free PMC article.

3

A doubly auxotrophic CHO-K1 cell line for the production of recombinant monoclonal antibodies.

Zhang Q, Jiang B, Du Z, Chasin LA. Zhang Q, et al. Among authors: du z. Biotechnol Bioeng. 2020 Aug;117(8):2401-2409. doi: 10.1002/bit.27367. Epub 2020 May 21. Biotechnol Bioeng. 2020. PMID: 32346859

4

Improving Antibody Production in Stably Transfected CHO Cells by CRISPR-Cas9-Mediated Inactivation of Genes Identified in a Large-Scale Screen with Chinese Hamster-Specific siRNAs.

Lin PC, Liu R, Alvin K, Wahyu S, Murgolo N, Ye J, Du Z, Song Z. Lin PC, et al. Among authors: du z. Biotechnol J. 2021 Mar;16(3):e2000267. doi: 10.1002/biot.202000267. Epub 2020 Nov 9. Biotechnol J. 2021. PMID: 33079482

5

Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4⁺ T Cells.

Coppola C, Hopkins B, Huhn S, Du Z, Huang Z, Kelly WJ. Coppola C, et al. Among authors: du z. Int J Mol Sci. 2020 Oct 22;21(21):7814. doi: 10.3390/ijms21217814. Int J Mol Sci. 2020. PMID: 33105566 Free PMC article.

6

Modulating tyrosine sulfation of recombinant antibodies in CHO cell culture by host selection and sodium chlorate supplementation.

Liu R, Zhang Y, Kumar A, Huhn S, Hullinger L, Du Z. Liu R, et al. Among authors: du z. Biotechnol J. 2021 Sep;16(9):e2100142. doi: 10.1002/biot.202100142. Epub 2021 Jun 20. Biotechnol J. 2021. PMID: 34081410

7

Improvement of the efficiency and quality in developing a new CHO host cell line.

Huhn SC, Ou Y, Tang X, Jiang B, Liu R, Lin H, Du Z. Huhn SC, et al. Among authors: du z. Biotechnol Prog. 2021 Sep;37(5):e3185. doi: 10.1002/btpr.3185. Epub 2021 Jun 26. Biotechnol Prog. 2021. PMID: 34142466

8

Retrospective assessment of clonality of a legacy cell line by analytical subcloning of the master cell bank.

Li GB, Pollard J, Liu R, Stevens RC, Quiroz J, Nelson MC, Manahan M, Murgolo N, Ehrick RS, Wallenstein EJ, Hughes J, Tsao YS, Zhao J, Du Z, Tugcu N, Pollard D. Li GB, et al. Among authors: du z. Biotechnol Prog. 2022 Jan;38(1):e3215. doi: 10.1002/btpr.3215. Epub 2021 Oct 20. Biotechnol Prog. 2022. PMID: 34586757

9

Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor.

Chang M, Huhn S, Nelson L, Betenbaugh M, Du Z. Chang M, et al. Among authors: du z. Biotechnol Bioeng. 2022 May;119(5):1189-1206. doi: 10.1002/bit.28050. Epub 2022 Feb 17. Biotechnol Bioeng. 2022. PMID: 35112712

10

A multiauxotrophic CHO cell line for the rapid isolation of producers of diverse or high levels of recombinant proteins.

Zhang Q, Jiang B, Nelson L, Huhn S, Du Z, Chasin LA. Zhang Q, et al. Among authors: du z. Biotechnol Bioeng. 2022 Jun;119(6):1392-1404. doi: 10.1002/bit.28074. Epub 2022 Mar 19. Biotechnol Bioeng. 2022. PMID: 35249214

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