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MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. Wienken M, et al. Among authors: dobbelstein m. Mol Cell. 2016 Jan 7;61(1):68-83. doi: 10.1016/j.molcel.2015.12.008. Epub 2015 Dec 31. Mol Cell. 2016. PMID: 26748827 Free PMC article.
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.
Sriraman A, Radovanovic M, Wienken M, Najafova Z, Li Y, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Oncotarget. 2016 May 31;7(22):31623-38. doi: 10.18632/oncotarget.9302. Oncotarget. 2016. PMID: 27183917 Free PMC article.
Fortifying p53 - beyond Mdm2 inhibitors.
Sriraman A, Li Y, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Aging (Albany NY). 2016 Sep 29;8(9):1836-1837. doi: 10.18632/aging.101073. Aging (Albany NY). 2016. PMID: 27688014 Free PMC article. No abstract available.
p53 Activity Results in DNA Replication Fork Processivity.
Klusmann I, Rodewald S, Müller L, Friedrich M, Wienken M, Li Y, Schulz-Heddergott R, Dobbelstein M. Klusmann I, et al. Among authors: dobbelstein m. Cell Rep. 2016 Nov 8;17(7):1845-1857. doi: 10.1016/j.celrep.2016.10.036. Cell Rep. 2016. PMID: 27829155 Free article.
Mdm2 as a chromatin modifier.
Wienken M, Moll UM, Dobbelstein M. Wienken M, et al. Among authors: dobbelstein m. J Mol Cell Biol. 2017 Feb 1;9(1):74-80. doi: 10.1093/jmcb/mjw046. J Mol Cell Biol. 2017. PMID: 27927750 Free PMC article. Review.
CDK4 inhibition diminishes p53 activation by MDM2 antagonists.
Sriraman A, Dickmanns A, Najafova Z, Johnsen SA, Dobbelstein M. Sriraman A, et al. Among authors: dobbelstein m. Cell Death Dis. 2018 Sep 11;9(9):918. doi: 10.1038/s41419-018-0968-0. Cell Death Dis. 2018. PMID: 30206211 Free PMC article.
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication.
Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M. Klusmann I, et al. Among authors: dobbelstein m. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11311-E11320. doi: 10.1073/pnas.1809592115. Epub 2018 Nov 9. Proc Natl Acad Sci U S A. 2018. PMID: 30413623 Free PMC article.
133 results