Dhavale DD - Search Results

1

Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.

Miller RL, Dhavale DD, O'Shea JY, Andruska KM, Liu J, Franklin EE, Buddhala C, Loftin SK, Cirrito JR, Perrin RJ, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT. Miller RL, et al. Among authors: dhavale dd. Ann Clin Transl Neurol. 2022 Feb;9(2):106-121. doi: 10.1002/acn3.51482. Epub 2022 Jan 21. Ann Clin Transl Neurol. 2022. PMID: 35060360 Free PMC article.

2

Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer's disease.

Sundaram GS, Dhavale D, Prior JL, Sivapackiam J, Laforest R, Kotzbauer P, Sharma V. Sundaram GS, et al. EJNMMI Res. 2015 Dec;5(1):112. doi: 10.1186/s13550-015-0112-4. Epub 2015 May 24. EJNMMI Res. 2015. PMID: 26061601 Free PMC article.

3

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Chu W, et al. J Med Chem. 2015 Aug 13;58(15):6002-17. doi: 10.1021/acs.jmedchem.5b00571. Epub 2015 Jul 31. J Med Chem. 2015. PMID: 26177091 Free PMC article.

4

Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease.

Sundaram GS, Dhavale DD, Prior JL, Yan P, Cirrito J, Rath NP, Laforest R, Cairns NJ, Lee JM, Kotzbauer PT, Sharma V. Sundaram GS, et al. Among authors: dhavale dd. Sci Rep. 2016 Nov 2;6:35636. doi: 10.1038/srep35636. Sci Rep. 2016. PMID: 27805057 Free PMC article.

5

A sensitive assay reveals structural requirements for α-synuclein fibril growth.

Dhavale DD, Tsai C, Bagchi DP, Engel LA, Sarezky J, Kotzbauer PT. Dhavale DD, et al. J Biol Chem. 2017 Jun 2;292(22):9034-9050. doi: 10.1074/jbc.M116.767053. Epub 2017 Apr 3. J Biol Chem. 2017. PMID: 28373279 Free PMC article.

6

Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength.

Barclay AM, Dhavale DD, Courtney JM, Kotzbauer PT, Rienstra CM. Barclay AM, et al. Among authors: dhavale dd. Biomol NMR Assign. 2018 Apr;12(1):195-199. doi: 10.1007/s12104-018-9808-5. Epub 2018 Feb 23. Biomol NMR Assign. 2018. PMID: 29476328 Free PMC article.

7

Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation.

Yue X, Dhavale DD, Li J, Luo Z, Liu J, Yang H, Mach RH, Kotzbauer PT, Tu Z. Yue X, et al. Among authors: dhavale dd. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1011-1019. doi: 10.1016/j.bmcl.2018.02.031. Epub 2018 Feb 16. Bioorg Med Chem Lett. 2018. PMID: 29482941 Free PMC article.

8

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules.

Hsieh CJ, Ferrie JJ, Xu K, Lee I, Graham TJA, Tu Z, Yu J, Dhavale D, Kotzbauer P, Petersson EJ, Mach RH. Hsieh CJ, et al. ACS Chem Neurosci. 2018 Nov 21;9(11):2521-2527. doi: 10.1021/acschemneuro.8b00177. Epub 2018 May 16. ACS Chem Neurosci. 2018. PMID: 29750499 Free PMC article.

9

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro.

Hsieh CJ, Xu K, Lee I, Graham TJA, Tu Z, Dhavale D, Kotzbauer P, Mach RH. Hsieh CJ, et al. ACS Omega. 2018 Apr 30;3(4):4486-4493. doi: 10.1021/acsomega.7b01897. Epub 2018 Apr 24. ACS Omega. 2018. PMID: 30221226 Free PMC article.

10

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.

Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI. Yamasaki TR, et al. Among authors: dhavale dd. J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471. Epub 2018 Nov 26. J Biol Chem. 2019. PMID: 30478174 Free PMC article.

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