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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro.
Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. Aillaud I, et al. Among authors: alkhashrom s. Alzheimers Res Ther. 2022 Jan 21;14(1):15. doi: 10.1186/s13195-022-00959-z. Alzheimers Res Ther. 2022. PMID: 35063014 Free PMC article.
High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity.
Muller YA, Häge S, Alkhashrom S, Höllriegl T, Weigert S, Dolles S, Hof K, Walzer SA, Egerer-Sieber C, Conrad M, Holst S, Lösing J, Sonntag E, Sticht H, Eichler J, Marschall M. Muller YA, et al. Among authors: alkhashrom s. J Biol Chem. 2020 Mar 6;295(10):3189-3201. doi: 10.1074/jbc.RA119.011546. Epub 2020 Jan 24. J Biol Chem. 2020. PMID: 31980459 Free PMC article.
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties.
Marschall M, Häge S, Conrad M, Alkhashrom S, Kicuntod J, Schweininger J, Kriegel M, Lösing J, Tillmanns J, Neipel F, Eichler J, Muller YA, Sticht H. Marschall M, et al. Among authors: alkhashrom s. Viruses. 2020 Jun 24;12(6):683. doi: 10.3390/v12060683. Viruses. 2020. PMID: 32599939 Free PMC article. Review.
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.
Schweininger J, Kriegel M, Häge S, Conrad M, Alkhashrom S, Lösing J, Weiler S, Tillmanns J, Egerer-Sieber C, Decker A, Lenac Roviš T, Eichler J, Sticht H, Marschall M, Muller YA. Schweininger J, et al. Among authors: alkhashrom s. J Biol Chem. 2022 Mar;298(3):101625. doi: 10.1016/j.jbc.2022.101625. Epub 2022 Jan 22. J Biol Chem. 2022. PMID: 35074430 Free PMC article.