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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro.
Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. Aillaud I, et al. Among authors: chandupatla rr. Alzheimers Res Ther. 2022 Jan 21;14(1):15. doi: 10.1186/s13195-022-00959-z. Alzheimers Res Ther. 2022. PMID: 35063014 Free PMC article.
Purification and Characterization of Low-n Tau Oligomers.
Kaniyappan S, Chandupatla RR, Mandelkow E. Kaniyappan S, et al. Among authors: chandupatla rr. Methods Mol Biol. 2018;1779:99-111. doi: 10.1007/978-1-4939-7816-8_8. Methods Mol Biol. 2018. PMID: 29886530
Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment.
Pir GJ, Choudhary B, Kaniyappan S, Chandupatla RR, Mandelkow E, Mandelkow EM, Wang Y. Pir GJ, et al. Among authors: chandupatla rr. Mol Neurobiol. 2019 May;56(5):3751-3767. doi: 10.1007/s12035-018-1326-z. Epub 2018 Sep 8. Mol Neurobiol. 2019. PMID: 30196394 Free PMC article.
The release and trans-synaptic transmission of Tau via exosomes.
Wang Y, Balaji V, Kaniyappan S, Krüger L, Irsen S, Tepper K, Chandupatla R, Maetzler W, Schneider A, Mandelkow E, Mandelkow EM. Wang Y, et al. Mol Neurodegener. 2017 Jan 13;12(1):5. doi: 10.1186/s13024-016-0143-y. Mol Neurodegener. 2017. PMID: 28086931 Free PMC article.