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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro.
Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. Aillaud I, et al. Among authors: mandelkow e. Alzheimers Res Ther. 2022 Jan 21;14(1):15. doi: 10.1186/s13195-022-00959-z. Alzheimers Res Ther. 2022. PMID: 35063014 Free PMC article.
Screening for inhibitors of tau polymerization.
Pickhardt M, von Bergen M, Gazova Z, Hascher A, Biernat J, Mandelkow EM, Mandelkow E. Pickhardt M, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2005 Apr;2(2):219-26. doi: 10.2174/1567205053585891. Curr Alzheimer Res. 2005. PMID: 15974921
The "jaws" of the tau-microtubule interaction.
Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: mandelkow e. J Biol Chem. 2007 Apr 20;282(16):12230-9. doi: 10.1074/jbc.M607159200. Epub 2007 Feb 15. J Biol Chem. 2007. PMID: 17307736 Free article.
Inhibition of tau aggregation in cell models of tauopathy.
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2007 Dec;4(5):544-6. doi: 10.2174/156720507783018307. Curr Alzheimer Res. 2007. PMID: 18220518 Review.
Structural characterization of binding of Cu(II) to tau protein.
Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. Soragni A, et al. Among authors: mandelkow e. Biochemistry. 2008 Oct 14;47(41):10841-51. doi: 10.1021/bi8008856. Epub 2008 Sep 20. Biochemistry. 2008. PMID: 18803399
Development of tau aggregation inhibitors for Alzheimer's disease.
Bulic B, Pickhardt M, Schmidt B, Mandelkow EM, Waldmann H, Mandelkow E. Bulic B, et al. Among authors: mandelkow em, mandelkow e. Angew Chem Int Ed Engl. 2009;48(10):1740-52. doi: 10.1002/anie.200802621. Angew Chem Int Ed Engl. 2009. PMID: 19189357 Review.
Structural polymorphism of 441-residue tau at single residue resolution.
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: mandelkow e. PLoS Biol. 2009 Feb 17;7(2):e34. doi: 10.1371/journal.pbio.1000034. PLoS Biol. 2009. PMID: 19226187 Free PMC article.
370 results