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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro.
Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn AHC, Zweckstetter M, Mandelkow E, Sticht H, Funke SA. Aillaud I, et al. Among authors: zweckstetter m. Alzheimers Res Ther. 2022 Jan 21;14(1):15. doi: 10.1186/s13195-022-00959-z. Alzheimers Res Ther. 2022. PMID: 35063014 Free PMC article.
The "jaws" of the tau-microtubule interaction.
Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: zweckstetter m. J Biol Chem. 2007 Apr 20;282(16):12230-9. doi: 10.1074/jbc.M607159200. Epub 2007 Feb 15. J Biol Chem. 2007. PMID: 17307736 Free article.
Structural characterization of binding of Cu(II) to tau protein.
Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. Soragni A, et al. Among authors: zweckstetter m. Biochemistry. 2008 Oct 14;47(41):10841-51. doi: 10.1021/bi8008856. Epub 2008 Sep 20. Biochemistry. 2008. PMID: 18803399
Structural polymorphism of 441-residue tau at single residue resolution.
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: zweckstetter m. PLoS Biol. 2009 Feb 17;7(2):e34. doi: 10.1371/journal.pbio.1000034. PLoS Biol. 2009. PMID: 19226187 Free PMC article.
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Kumar S, et al. Among authors: zweckstetter m. EMBO J. 2011 Jun 1;30(11):2255-65. doi: 10.1038/emboj.2011.138. Epub 2011 Apr 28. EMBO J. 2011. PMID: 21527912 Free PMC article.
294 results