Itai A - Search Results

1

Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.

Kato T, Ohara T, Suzuki N, Muto S, Tokuyama R, Mizutani M, Fukasawa H, Matsumura KI, Itai A. Kato T, et al. Among authors: itai a. Bioorg Med Chem Lett. 2022 Mar 1;59:128567. doi: 10.1016/j.bmcl.2022.128567. Epub 2022 Jan 19. Bioorg Med Chem Lett. 2022. PMID: 35063634

2

Rational automatic search method for stable docking models of protein and ligand.

Mizutani MY, Tomioka N, Itai A. Mizutani MY, et al. Among authors: itai a. J Mol Biol. 1994 Oct 21;243(2):310-26. doi: 10.1006/jmbi.1994.1656. J Mol Biol. 1994. PMID: 7932757

3

Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.

Endo Y, Takehana S, Ohno M, Driedger PE, Stabel S, Mizutani MY, Tomioka N, Itai A, Shudo K. Endo Y, et al. Among authors: itai a. J Med Chem. 1998 Apr 23;41(9):1476-96. doi: 10.1021/jm970704s. J Med Chem. 1998. PMID: 9554881

4

Novel thiazolidinedione derivatives with retinoid synergistic activity.

Ebisawa M, Kawachi E, Fukasawa H, Hashimoto Y, Itai A, Shudo K, Kagechika H. Ebisawa M, et al. Among authors: itai a. Biol Pharm Bull. 1998 May;21(5):547-9. doi: 10.1248/bpb.21.547. Biol Pharm Bull. 1998. PMID: 9635519 Free article.

5

Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety.

Endo Y, Shimazu M, Fukasawa H, Driedger PE, Kimura K, Tomioka N, Itai A, Shudo K. Endo Y, et al. Among authors: itai a. Bioorg Med Chem Lett. 1999 Jan 18;9(2):173-8. doi: 10.1016/s0960-894x(98)00724-0. Bioorg Med Chem Lett. 1999. PMID: 10021922

6

Structure-activity study of estrogenic agonists bearing dicarba-closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules.

Endo Y, Iijima T, Amakoshi Y, Kubo A, Itai A. Endo Y, et al. Among authors: itai a. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3313-8. doi: 10.1016/s0960-894x(99)00596-x. Bioorg Med Chem Lett. 1999. PMID: 10612591

7

Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids.

Ohta K, Kawachi E, Inoue N, Fukasawa H, Hashimoto Y, Itai A, Kagechika H. Ohta K, et al. Among authors: itai a. Chem Pharm Bull (Tokyo). 2000 Oct;48(10):1504-13. doi: 10.1248/cpb.48.1504. Chem Pharm Bull (Tokyo). 2000. PMID: 11045459

8

Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.

Kondo K, Ogawa H, Shinohara T, Kurimura M, Tanada Y, Kan K, Yamashita H, Nakamura S, Hirano T, Yamamura Y, Mori T, Tominaga M, Itai A. Kondo K, et al. Among authors: itai a. J Med Chem. 2000 Nov 16;43(23):4388-97. doi: 10.1021/jm000108p. J Med Chem. 2000. PMID: 11087564

9

Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters.

Endo Y, Iijima T, Yamakoshi Y, Fukasawa H, Miyaura C, Inada M, Kubo A, Itai A. Endo Y, et al. Among authors: itai a. Chem Biol. 2001 Apr;8(4):341-55. doi: 10.1016/s1074-5521(01)00016-3. Chem Biol. 2001. PMID: 11325590

10

Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.

Iwata Y, Arisawa M, Hamada R, Kita Y, Mizutani MY, Tomioka N, Itai A, Miyamoto S. Iwata Y, et al. Among authors: itai a. J Med Chem. 2001 May 24;44(11):1718-28. doi: 10.1021/jm000483h. J Med Chem. 2001. PMID: 11356107

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