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Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function.
Martin DP, Lytras S, Lucaci AG, Maier W, Grüning B, Shank SD, Weaver S, MacLean OA, Orton RJ, Lemey P, Boni MF, Tegally H, Harkins G, Scheepers C, Bhiman JN, Everatt J, Amoako DG, San JE, Giandhari J, Sigal A; NGS-SA; Williamson C, Hsiao NY, von Gottberg A, De Klerk A, Shafer RW, Robertson DL, Wilkinson RJ, Sewell BT, Lessells R, Nekrutenko A, Greaney AJ, Starr TN, Bloom JD, Murrell B, Wilkinson E, Gupta RK, de Oliveira T, Kosakovsky Pond SL. Martin DP, et al. Among authors: shafer rw. bioRxiv [Preprint]. 2022 Jan 18:2022.01.14.476382. doi: 10.1101/2022.01.14.476382. bioRxiv. 2022. Update in: Mol Biol Evol. 2022 Apr 11;39(4):msac061. doi: 10.1093/molbev/msac061 PMID: 35075456 Free PMC article. Updated. Preprint.
HIV-1 5'-Leader Mutations in Plasma Viruses Before and After the Development of Reverse Transcriptase Inhibitor-Resistance Mutations.
Nouhin J, Tzou PL, Rhee SY, Sahoo MK, Pinsky BA, Krupkin M, Puglisi JD, Puglisi EV, Shafer RW. Nouhin J, et al. Among authors: shafer rw. medRxiv [Preprint]. 2023 Aug 29:2023.06.04.23290942. doi: 10.1101/2023.06.04.23290942. medRxiv. 2023. Update in: J Gen Virol. 2023 Oct;104(10). doi: 10.1099/jgv.0.001898 PMID: 37333388 Free PMC article. Updated. Preprint.
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis.
Bhimraj A, Falck-Ytter Y, Kim AY, Li JZ, Baden LR, Johnson S, Shafer RW, Shoham S, Tebas P, Bedimo R, Cheng VC, Chew KW, Chiotos K, Daar ES, Dzierba AL, Glidden DV, Hardy EJ, Martin GS, MacBrayne C, Nadig N, Nakamura MM, Shumaker AH, Tien P, Loveless J, Morgan RL, Gandhi RT. Bhimraj A, et al. Among authors: shafer rw. Clin Infect Dis. 2024 Oct 29:ciae435. doi: 10.1093/cid/ciae435. Online ahead of print. Clin Infect Dis. 2024. PMID: 39471458
Emerging SARS-CoV-2 Resistance After Antiviral Treatment.
Tamura TJ, Choudhary MC, Deo R, Yousuf F, Gomez AN, Edelstein GE, Boucau J, Glover OT, Barry M, Gilbert RF, Reynolds Z, Li Y, Tien D, Vyas TD, Passell E, Su K, Drapkin S, Abar EG, Kawano Y, Sparks JA, Wallace ZS, Vyas JM, Shafer RW, Siedner MJ, Barczak AK, Lemieux JE, Li JZ; POSITIVES Study Team. Tamura TJ, et al. Among authors: shafer rw. JAMA Netw Open. 2024 Sep 3;7(9):e2435431. doi: 10.1001/jamanetworkopen.2024.35431. JAMA Netw Open. 2024. PMID: 39320890 Free PMC article.
Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial.
Geng LN, Bonilla H, Hedlin H, Jacobson KB, Tian L, Jagannathan P, Yang PC, Subramanian AK, Liang JW, Shen S, Deng Y, Shaw BJ, Botzheim B, Desai M, Pathak D, Jazayeri Y, Thai D, O'Donnell A, Mohaptra S, Leang Z, Reynolds GZM, Brooks EF, Bhatt AS, Shafer RW, Miglis MG, Quach T, Tiwari A, Banerjee A, Lopez RN, De Jesus M, Charnas LR, Utz PJ, Singh U. Geng LN, et al. Among authors: shafer rw. JAMA Intern Med. 2024 Sep 1;184(9):1024-1034. doi: 10.1001/jamainternmed.2024.2007. JAMA Intern Med. 2024. PMID: 38848477 Free PMC article. Clinical Trial.
Combating antimicrobial resistance in malaria, HIV and tuberculosis.
Duffey M, Shafer RW, Timm J, Burrows JN, Fotouhi N, Cockett M, Leroy D. Duffey M, et al. Among authors: shafer rw. Nat Rev Drug Discov. 2024 Jun;23(6):461-479. doi: 10.1038/s41573-024-00933-4. Epub 2024 May 15. Nat Rev Drug Discov. 2024. PMID: 38750260 Review.
283 results