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Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase.
Agostinucci K, Hutcheson R, Hossain S, Pascale JV, Villegas E, Zhang F, Adebesin AM, Falck JR, Gupte S, Garcia V, Schwartzman ML. Agostinucci K, et al. Among authors: gupte s. J Hypertens. 2022 Mar 1;40(3):498-511. doi: 10.1097/HJH.0000000000003038. J Hypertens. 2022. PMID: 35081581 Free PMC article.
Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.
Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA. Kizub IV, et al. Among authors: gupte sa. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L772-83. doi: 10.1152/ajplung.00377.2015. Epub 2016 Feb 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26895643 Free PMC article.
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Lakhkar A, Dhagia V, Joshi SR, Gotlinger K, Patel D, Sun D, Wolin MS, Schwartzman ML, Gupte SA. Lakhkar A, et al. Among authors: gupte sa. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1107-17. doi: 10.1152/ajpheart.00961.2015. Epub 2016 Feb 26. Am J Physiol Heart Circ Physiol. 2016. PMID: 26921441 Free PMC article.
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P. Soler A, et al. Among authors: gupte sa. J Mol Cell Cardiol. 2018 Apr;117:88-99. doi: 10.1016/j.yjmcc.2018.02.005. Epub 2018 Feb 8. J Mol Cell Cardiol. 2018. PMID: 29428638 Free PMC article.
Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99].
Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P. Soler A, et al. Among authors: gupte sa. J Mol Cell Cardiol. 2018 Aug;121:308. doi: 10.1016/j.yjmcc.2018.03.015. Epub 2018 Apr 4. J Mol Cell Cardiol. 2018. PMID: 29625729 No abstract available.
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension.
D'Addario CA, Matsumura S, Kitagawa A, Lainer GM, Zhang F, D'silva M, Khan MY, Froogh G, Gruzdev A, Zeldin DC, Schwartzman ML, Gupte SA. D'Addario CA, et al. Among authors: gupte sa. Vascul Pharmacol. 2023 Dec;153:107235. doi: 10.1016/j.vph.2023.107235. Epub 2023 Sep 23. Vascul Pharmacol. 2023. PMID: 37742819 Free PMC article.
G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease.
Signoretti C, Matsumura S, Fatehi S, D'Silva M, Mathew R, Cendali F, D'Alessandro A, Alam SMS, Garcia V, Miano JM, Gupte SA. Signoretti C, et al. Among authors: gupte sa. J Am Heart Assoc. 2024 Oct;13(19):e035174. doi: 10.1161/JAHA.123.035174. Epub 2024 Sep 18. J Am Heart Assoc. 2024. PMID: 39291493 Free PMC article.
353 results