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BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals.
Srivastava R, Cao Z, Nedeva C, Naim S, Bachmann D, Rabachini T, Gangoda L, Shahi S, Glab J, Menassa J, Osellame L, Nelson T, Fernandez-Marrero Y, Brown F, Wei A, Ke F, O'Reilly L, Doerflinger M, Allison C, Kueh A, Ramsay R, Smith BJ, Mathivanan S, Kaufmann T, Puthalakath H. Srivastava R, et al. Among authors: smith bj. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15469-15474. doi: 10.1073/pnas.1904523116. Epub 2019 Jul 16. Proc Natl Acad Sci U S A. 2019. PMID: 31311867 Free PMC article.
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, Yang H, Baell JB. Sleebs BE, et al. Among authors: smith ml, smith bj. J Med Chem. 2011 Mar 24;54(6):1914-26. doi: 10.1021/jm101596e. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366295
α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH, Fairlie WD. Checco JW, et al. Among authors: smith bj. J Am Chem Soc. 2015 Sep 9;137(35):11365-75. doi: 10.1021/jacs.5b05896. Epub 2015 Aug 28. J Am Chem Soc. 2015. PMID: 26317395 Free PMC article.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE. Brouwer JM, et al. Among authors: smith bj. Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. Mol Cell. 2017. PMID: 29149594 Free article.
"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.
Rege NK, Liu M, Dhayalan B, Chen YS, Smith NA, Rahimi L, Sun J, Guo H, Yang Y, Haataja L, Phillips NFB, Whittaker J, Smith BJ, Arvan P, Ismail-Beigi F, Weiss MA. Rege NK, et al. Among authors: smith bj, smith na. J Biol Chem. 2020 Mar 6;295(10):3080-3098. doi: 10.1074/jbc.RA119.011389. Epub 2020 Jan 31. J Biol Chem. 2020. PMID: 32005662 Free PMC article.
Diversity in the intrinsic apoptosis pathway of nematodes.
Young ND, Harris TJ, Evangelista M, Tran S, Wouters MA, Soares da Costa TP, Kershaw NJ, Gasser RB, Smith BJ, Lee EF, Fairlie WD. Young ND, et al. Among authors: smith bj. Commun Biol. 2020 Aug 28;3(1):478. doi: 10.1038/s42003-020-01208-5. Commun Biol. 2020. PMID: 32859965 Free PMC article.
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Nguyen W, Lee EF, Evangelista M, Lee M, Harris TJ, Colman PM, Smith NA, Williams LB, Jarman KE, Lowes KN, Haeberli C, Keiser J, Smith BJ, Fairlie WD, Sleebs BE. Nguyen W, et al. Among authors: smith bj, smith na. ACS Infect Dis. 2021 May 14;7(5):1143-1163. doi: 10.1021/acsinfecdis.0c00700. Epub 2021 Feb 1. ACS Infect Dis. 2021. PMID: 33523649
1,332 results