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269 results

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Page 1
Molecular Basis of Small-Molecule Binding to α-Synuclein.
Robustelli P, Ibanez-de-Opakua A, Campbell-Bezat C, Giordanetto F, Becker S, Zweckstetter M, Pan AC, Shaw DE. Robustelli P, et al. Among authors: shaw de. J Am Chem Soc. 2022 Feb 16;144(6):2501-2510. doi: 10.1021/jacs.1c07591. Epub 2022 Feb 7. J Am Chem Soc. 2022. PMID: 35130691 Free PMC article.
How does a drug molecule find its target binding site?
Shan Y, Kim ET, Eastwood MP, Dror RO, Seeliger MA, Shaw DE. Shan Y, et al. Among authors: shaw de. J Am Chem Soc. 2011 Jun 22;133(24):9181-3. doi: 10.1021/ja202726y. Epub 2011 May 13. J Am Chem Soc. 2011. PMID: 21545110 Free PMC article.
Pathway and mechanism of drug binding to G-protein-coupled receptors.
Dror RO, Pan AC, Arlow DH, Borhani DW, Maragakis P, Shan Y, Xu H, Shaw DE. Dror RO, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13118-23. doi: 10.1073/pnas.1104614108. Epub 2011 Jul 21. Proc Natl Acad Sci U S A. 2011. PMID: 21778406 Free PMC article.
Activation mechanism of the β2-adrenergic receptor.
Dror RO, Arlow DH, Maragakis P, Mildorf TJ, Pan AC, Xu H, Borhani DW, Shaw DE. Dror RO, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18684-9. doi: 10.1073/pnas.1110499108. Epub 2011 Oct 26. Proc Natl Acad Sci U S A. 2011. PMID: 22031696 Free PMC article.
Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Kruse AC, et al. Among authors: shaw de. Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867. Nature. 2012. PMID: 22358844 Free PMC article.
The dynamic process of β(2)-adrenergic receptor activation.
Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. Nygaard R, et al. Among authors: shaw de. Cell. 2013 Jan 31;152(3):532-42. doi: 10.1016/j.cell.2013.01.008. Cell. 2013. PMID: 23374348 Free PMC article.
Molecular determinants of drug-receptor binding kinetics.
Pan AC, Borhani DW, Dror RO, Shaw DE. Pan AC, et al. Among authors: shaw de. Drug Discov Today. 2013 Jul;18(13-14):667-73. doi: 10.1016/j.drudis.2013.02.007. Epub 2013 Feb 27. Drug Discov Today. 2013. PMID: 23454741 Review.
Transitions to catalytically inactive conformations in EGFR kinase.
Shan Y, Arkhipov A, Kim ET, Pan AC, Shaw DE. Shan Y, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7270-5. doi: 10.1073/pnas.1220843110. Epub 2013 Apr 1. Proc Natl Acad Sci U S A. 2013. PMID: 23576739 Free PMC article.
269 results