Long BR - Search Results

1

Confirmatory detection of neutralizing antibodies to AAV gene therapy using a cell-based transduction inhibition assay.

Kasprzyk T, Triffault S, Long BR, Zoog SJ, Vettermann C. Kasprzyk T, et al. Among authors: long br. Mol Ther Methods Clin Dev. 2022 Jan 7;24:222-229. doi: 10.1016/j.omtm.2022.01.004. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35141351 Free PMC article.

2

Antibodies that neutralize cellular uptake of elosulfase alfa are not associated with reduced efficacy or pharmacodynamic effect in individuals with Morquio A syndrome.

Melton AC, Soon RK Jr, Tompkins T, Long B, Schweighardt B, Qi Y, Vitelli C, Bagri A, Decker C, O'Neill CA, Zoog SJ, Jesaitis L. Melton AC, et al. J Immunol Methods. 2017 Jan;440:41-51. doi: 10.1016/j.jim.2016.10.006. Epub 2016 Oct 24. J Immunol Methods. 2017. PMID: 27789297 Free article. Clinical Trial.

3

Strategy to detect pre-existing immunity to AAV gene therapy.

Falese L, Sandza K, Yates B, Triffault S, Gangar S, Long B, Tsuruda L, Carter B, Vettermann C, Zoog SJ, Fong S. Falese L, et al. Gene Ther. 2017 Dec;24(12):768-778. doi: 10.1038/gt.2017.95. Epub 2017 Nov 6. Gene Ther. 2017. PMID: 29106404 Free PMC article.

4

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy.

Long BR, Sandza K, Holcomb J, Crockett L, Hayes GM, Arens J, Fonck C, Tsuruda LS, Schweighardt B, O'Neill CA, Zoog S, Vettermann C. Long BR, et al. Mol Ther Methods Clin Dev. 2019 Apr 11;13:440-452. doi: 10.1016/j.omtm.2019.03.006. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2019. PMID: 31193016 Free PMC article.

5

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A.

Long BR, Veron P, Kuranda K, Hardet R, Mitchell N, Hayes GM, Wong WY, Lau K, Li M, Hock MB, Zoog SJ, Vettermann C, Mingozzi F, Schweighardt B. Long BR, et al. Mol Ther. 2021 Feb 3;29(2):597-610. doi: 10.1016/j.ymthe.2020.12.008. Epub 2020 Dec 10. Mol Ther. 2021. PMID: 33309883 Free PMC article.

6

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates.

Yang F, Patton K, Kasprzyk T, Long B, Gupta S, Zoog SJ, Tracy K, Vettermann C. Yang F, et al. Gene Ther. 2022 Feb;29(1-2):41-54. doi: 10.1038/s41434-020-00214-w. Epub 2021 Jan 11. Gene Ther. 2022. PMID: 33432123 Free PMC article.

7

Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method.

Patton KS, Harrison MT, Long BR, Lau K, Holcomb J, Owen R, Kasprzyk T, Janetzki S, Zoog SJ, Vettermann C. Patton KS, et al. Among authors: long br. Mol Ther Methods Clin Dev. 2021 May 29;22:183-195. doi: 10.1016/j.omtm.2021.05.012. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34485604 Free PMC article.

8

Evaluation of the Humoral Response to Adeno-Associated Virus-Based Gene Therapy Modalities Using Total Antibody Assays.

Gorovits B, Azadeh M, Buchlis G, Harrison T, Havert M, Jawa V, Long B, McNally J, Milton M, Nelson R, O'Dell M, Richards K, Vettermann C, Wu B. Gorovits B, et al. AAPS J. 2021 Sep 16;23(6):108. doi: 10.1208/s12248-021-00628-3. AAPS J. 2021. PMID: 34529177 Free PMC article. Review.

9

Evaluation of Cellular Immune Response to Adeno-Associated Virus-Based Gene Therapy.

Gorovits B, Azadeh M, Buchlis G, Fiscella M, Harrison T, Havert M, Janetzki S, Jawa V, Long B, Mahnke YD, McDermott A, Milton M, Nelson R, Vettermann C, Wu B. Gorovits B, et al. AAPS J. 2023 Apr 26;25(3):47. doi: 10.1208/s12248-023-00814-5. AAPS J. 2023. PMID: 37101079 Free PMC article. Review.

10

Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements.

Braun M, Lange C, Schatz P, Long B, Stanta J, Gorovits B, Tarcsa E, Jawa V, Yang TY, Lembke W, Miller N, McBlane F, Christodoulou L, Yuill D, Milton M. Braun M, et al. Mol Ther Methods Clin Dev. 2024 Feb 20;32(1):101217. doi: 10.1016/j.omtm.2024.101217. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38496304 Free PMC article. Review.

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