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Page 1
Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.
Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R 3rd, Narayan S, Hou Z, Economides AN, Hikida T, Wetsel WC, Deisseroth K, Mori S, Brandon NJ, Tanaka M, Ishizuka K, Houslay MD, Saudou F, Dzirasa K, Sawa A, Tomoda T. Jaaro-Peled H, et al. Among authors: brandon nj. Mol Psychiatry. 2022 Mar;27(3):1805-1815. doi: 10.1038/s41380-021-01389-3. Epub 2022 Feb 14. Mol Psychiatry. 2022. PMID: 35165396 Free PMC article.
DISC1 regulates trafficking and processing of APP and Aβ generation.
Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. Shahani N, et al. Among authors: brandon nj. Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16. Mol Psychiatry. 2015. PMID: 25224257 Free PMC article.
How has DISC1 enabled drug discovery?
Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. Wang Q, et al. Among authors: brandon nj. Mol Cell Neurosci. 2008 Feb;37(2):187-95. doi: 10.1016/j.mcn.2007.10.006. Epub 2007 Oct 23. Mol Cell Neurosci. 2008. PMID: 18055216 Review.
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. Wang Q, et al. Among authors: brandon nj. Mol Psychiatry. 2011 Oct;16(10):1006-23. doi: 10.1038/mp.2010.87. Epub 2010 Sep 14. Mol Psychiatry. 2011. PMID: 20838393 Free PMC article.
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A. Hayashi-Takagi A, et al. Among authors: brandon nj. Nat Neurosci. 2010 Mar;13(3):327-32. doi: 10.1038/nn.2487. Epub 2010 Feb 7. Nat Neurosci. 2010. PMID: 20139976 Free PMC article.
DISC1 at 10: connecting psychiatric genetics and neuroscience.
Porteous DJ, Millar JK, Brandon NJ, Sawa A. Porteous DJ, et al. Among authors: brandon nj. Trends Mol Med. 2011 Dec;17(12):699-706. doi: 10.1016/j.molmed.2011.09.002. Epub 2011 Oct 19. Trends Mol Med. 2011. PMID: 22015021 Free PMC article. Review.
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.
Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH. Porteous DJ, et al. Among authors: brandon nj. Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160. Mol Psychiatry. 2014. PMID: 24457522 Free PMC article. No abstract available.
155 results