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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
Muik A, Garralda E, Altintas I, Gieseke F, Geva R, Ben-Ami E, Maurice-Dror C, Calvo E, LoRusso PM, Alonso G, Rodriguez-Ruiz ME, Schoedel KB, Blum JM, Sänger B, Salcedo TW, Burm SM, Stanganello E, Verzijl D, Vascotto F, Sette A, Quinkhardt J, Plantinga TS, Toker A, van den Brink EN, Fereshteh M, Diken M, Satijn D, Kreiter S, Breij ECW, Bajaj G, Lagkadinou E, Sasser K, Türeci Ö, Forssmann U, Ahmadi T, Şahin U, Jure-Kunkel M, Melero I. Muik A, et al. Among authors: sette a. Cancer Discov. 2022 May 2;12(5):1248-1265. doi: 10.1158/2159-8290.CD-21-1345. Cancer Discov. 2022. PMID: 35176764 Free PMC article. Clinical Trial.
The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity.
Edwards CJ, Sette A, Cox C, Di Fiore B, Wyre C, Sydoruk D, Yadin D, Hayes P, Stelter S, Bartlett PD, Zuazo M, Garcia-Granda MJ, Benedetti G, Fiaska S, Birkett NR, Teng Y, Enever C, Arasanz H, Bocanegra A, Chocarro L, Fernandez G, Vera R, Archer B, Osuch I, Lewandowska M, Surani YM, Kochan G, Escors D, Legg J, Pierce AJ. Edwards CJ, et al. Among authors: sette a. Br J Cancer. 2022 May;126(8):1168-1177. doi: 10.1038/s41416-021-01684-4. Epub 2021 Dec 30. Br J Cancer. 2022. PMID: 34969998 Free PMC article.
hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma.
Lastraioli E, Perrone G, Sette A, Fiore A, Crociani O, Manoli S, D'Amico M, Masselli M, Iorio J, Callea M, Borzomati D, Nappo G, Bartolozzi F, Santini D, Bencini L, Farsi M, Boni L, Di Costanzo F, Schwab A, Onetti Muda A, Coppola R, Arcangeli A. Lastraioli E, et al. Among authors: sette a. Br J Cancer. 2015 Mar 17;112(6):1076-87. doi: 10.1038/bjc.2015.28. Br J Cancer. 2015. PMID: 25719829 Free PMC article.
Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses.
Bayarri-Olmos R, Sutta A, Rosbjerg A, Mortensen MM, Helgstrand C, Nielsen PF, Pérez-Alós L, González-García B, Johnsen LB, Matthiesen F, Egebjerg T, Hansen CB, Sette A, Grifoni A, Antunes RDS, Garred P. Bayarri-Olmos R, et al. Among authors: sette a. Front Immunol. 2024 Dec 10;15:1412873. doi: 10.3389/fimmu.2024.1412873. eCollection 2024. Front Immunol. 2024. PMID: 39720734 Free PMC article.
Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults.
Kometani K, Yorimitsu T, Jo N, Yamaguchi E, Kikuchi O, Fukahori M, Sawada T, Tsujimoto Y, Sunami A, Li M, Ito T, Pretemer Y, Gao Y, Hidaka Y, Yamamoto M, Kaku N, Nakagama Y, Kido Y, Grifoni A, Sette A, Nagao M, Morita S, Nakajima TE, Muto M, Hamazaki Y. Kometani K, et al. Among authors: sette a. Front Immunol. 2024 Dec 9;15:1455334. doi: 10.3389/fimmu.2024.1455334. eCollection 2024. Front Immunol. 2024. PMID: 39717779 Free PMC article.
Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2.
Ramirez SI, Lopez PG, Faraji F, Parikh UM, Heaps A, Ritz J, Moser C, Eron JJ, Wohl D, Currier J, Daar ES, Greninger A, Klekotka P, Grifoni A, Weiskopf D, Sette A, Peters B, Hughes MD, Chew KW, Smith DM, Crotty S; Accelerating COVID-19 Therapeutic Interventions and Vaccines-2 (ACTIV-2)/A5401 Study Team. Ramirez SI, et al. Among authors: sette a. JCI Insight. 2024 Dec 20;9(24):e186078. doi: 10.1172/jci.insight.186078. JCI Insight. 2024. PMID: 39704169 Free PMC article.
Patterns and cofactors of polyfunctional mycobacteria-specific T cell response restoration following 6-month antiretroviral treatment in children living with HIV.
Day CL, Njuguna IN, Cranmer LM, Whatney WE, Pearson RA, Lindestam Arlehamn CS, Sette A, LaCourse SM, Escudero JN, Sasser LE, Mugo C, Okinyi HM, Maleche-Obimbo E, Wamalwa DC, John-Stewart GC. Day CL, et al. Among authors: sette a. J Infect Dis. 2024 Dec 18:jiae630. doi: 10.1093/infdis/jiae630. Online ahead of print. J Infect Dis. 2024. PMID: 39693245
1,128 results