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Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.
Bost JP, Ojansivu M, Munson MJ, Wesén E, Gallud A, Gupta D, Gustafsson O, Saher O, Rädler J, Higgins SG, Lehto T, Holme MN, Dahlén A, Engkvist O, Strömstedt PE, Andersson S, Edvard Smith CI, Stevens MM, Esbjörner EK, Collén A, El Andaloussi S. Bost JP, et al. Among authors: andersson s. Commun Biol. 2022 Mar 1;5(1):185. doi: 10.1038/s42003-022-03132-2. Commun Biol. 2022. PMID: 35233031 Free PMC article.
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
Knerr L, Prakash TP, Lee R, Drury Iii WJ, Nikan M, Fu W, Pirie E, Maria L, Valeur E, Hayen A, Ölwegård-Halvarsson M, Broddefalk J, Ämmälä C, Østergaard ME, Meuller J, Sundström L, Andersson P, Janzén D, Jansson-Löfmark R, Seth PP, Andersson S. Knerr L, et al. Among authors: andersson s, andersson p. J Am Chem Soc. 2021 Mar 10;143(9):3416-3429. doi: 10.1021/jacs.0c12043. Epub 2021 Feb 24. J Am Chem Soc. 2021. PMID: 33626278
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.
Paramasivam P, Franke C, Stöter M, Höijer A, Bartesaghi S, Sabirsh A, Lindfors L, Arteta MY, Dahlén A, Bak A, Andersson S, Kalaidzidis Y, Bickle M, Zerial M. Paramasivam P, et al. Among authors: andersson s. J Cell Biol. 2022 Feb 7;221(2):e202110137. doi: 10.1083/jcb.202110137. Epub 2021 Dec 9. J Cell Biol. 2022. PMID: 34882187 Free PMC article.
NanoSIMS Imaging Reveals the Impact of Ligand-ASO Conjugate Stability on ASO Subcellular Distribution.
Kay E, Stulz R, Becquart C, Lovric J, Tängemo C, Thomen A, Baždarević D, Najafinobar N, Dahlén A, Pielach A, Fernandez-Rodriguez J, Strömberg R, Ämmälä C, Andersson S, Kurczy M. Kay E, et al. Among authors: andersson s. Pharmaceutics. 2022 Feb 21;14(2):463. doi: 10.3390/pharmaceutics14020463. Pharmaceutics. 2022. PMID: 35214195 Free PMC article.
Tissue pharmacokinetics of antisense oligonucleotides.
Bäckström E, Bonetti A, Johnsson P, Öhlin S, Dahlén A, Andersson P, Andersson S, Gennemark P. Bäckström E, et al. Among authors: andersson s, andersson p. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102133. doi: 10.1016/j.omtn.2024.102133. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38419941 Free PMC article.
Targeted delivery of antisense oligonucleotides to pancreatic β-cells.
Ämmälä C, Drury WJ 3rd, Knerr L, Ahlstedt I, Stillemark-Billton P, Wennberg-Huldt C, Andersson EM, Valeur E, Jansson-Löfmark R, Janzén D, Sundström L, Meuller J, Claesson J, Andersson P, Johansson C, Lee RG, Prakash TP, Seth PP, Monia BP, Andersson S. Ämmälä C, et al. Among authors: andersson s, andersson em, andersson p. Sci Adv. 2018 Oct 17;4(10):eaat3386. doi: 10.1126/sciadv.aat3386. eCollection 2018 Oct. Sci Adv. 2018. PMID: 30345352 Free PMC article.
1,906 results