Overgaard MT - Search Results

1

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa.

Sorensen AB, Greisen PJ, Madsen JJ, Lund J, Andersen G, Wulff-Larsen PG, Pedersen AA, Gandhi PS, Overgaard MT, Østergaard H, Olsen OH. Sorensen AB, et al. Among authors: overgaard mt. Sci Rep. 2022 Mar 8;12(1):3747. doi: 10.1038/s41598-022-07620-7. Sci Rep. 2022. PMID: 35260627 Free PMC article.

2

Calmodulin in a heartbeat.

Sorensen AB, Søndergaard MT, Overgaard MT. Sorensen AB, et al. Among authors: overgaard mt. FEBS J. 2013 Nov;280(21):5511-32. doi: 10.1111/febs.12337. Epub 2013 Jun 18. FEBS J. 2013. PMID: 23663249 Free article. Review.

3

ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.

Lund J, Olsen OH, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT. Lund J, et al. Among authors: overgaard mt. J Biol Chem. 2013 Jul 19;288(29):21367-21375. doi: 10.1074/jbc.M113.474536. Epub 2013 Jun 10. J Biol Chem. 2013. PMID: 23754285 Free PMC article.

4

Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex.

Lund J, Søndergaard MT, Conover CA, Overgaard MT. Lund J, et al. Among authors: overgaard mt. J Mol Endocrinol. 2014 Jun;52(3):345-55. doi: 10.1530/JME-13-0184. Epub 2014 Mar 6. J Mol Endocrinol. 2014. PMID: 24604839

5

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes.

Søndergaard MT, Sorensen AB, Skov LL, Kjaer-Sorensen K, Bauer MC, Nyegaard M, Linse S, Oxvig C, Overgaard MT. Søndergaard MT, et al. Among authors: overgaard mt. FEBS J. 2015 Feb;282(4):803-16. doi: 10.1111/febs.13184. Epub 2015 Jan 14. FEBS J. 2015. PMID: 25557436 Free article.

6

Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.

Lund J, Troeberg L, Kjeldal H, Olsen OH, Nagase H, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT. Lund J, et al. Among authors: overgaard mt. J Biol Chem. 2015 Mar 6;290(10):6620-9. doi: 10.1074/jbc.M114.601724. Epub 2015 Jan 6. J Biol Chem. 2015. PMID: 25564618 Free PMC article.

7

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen AB, Madsen JJ, Svensson LA, Pedersen AA, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Sorensen AB, et al. Among authors: overgaard mt. J Biol Chem. 2016 Feb 26;291(9):4671-83. doi: 10.1074/jbc.M115.698613. Epub 2015 Dec 22. J Biol Chem. 2016. PMID: 26694616 Free PMC article.

8

Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma.

Lund J, Elimar Bitsch AM, Grønbech Rasch M, Enoksson M, Troeberg L, Nagase H, Loftager M, Overgaard MT, Petersen HH. Lund J, et al. Among authors: overgaard mt. MAbs. 2018 Jan;10(1):118-128. doi: 10.1080/19420862.2017.1395541. Epub 2017 Nov 29. MAbs. 2018. PMID: 29185848 Free PMC article.

9

Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.

Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH. Sorensen AB, et al. Among authors: overgaard mt. Biophys J. 2019 May 21;116(10):1823-1835. doi: 10.1016/j.bpj.2019.03.024. Epub 2019 Apr 2. Biophys J. 2019. PMID: 31003762 Free PMC article.

10

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.

Sorensen AB, Tuneew I, Svensson LA, Persson E, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Sorensen AB, et al. Among authors: overgaard mt. J Biol Chem. 2020 Jan 10;295(2):517-528. doi: 10.1074/jbc.RA119.009183. Epub 2019 Dec 4. J Biol Chem. 2020. PMID: 31801825 Free PMC article.

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