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Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues.
Nelson CE, Namasivayam S, Foreman TW, Kauffman KD, Sakai S, Dorosky DE, Lora NE; NIAID/DIR Tuberculosis Imaging Program; Brooks K, Potter EL, Garza NL, Lafont BAP, Johnson RF, Roederer M, Sher A, Weiskopf D, Sette A, de Wit E, Hickman HD, Brenchley JM, Via LE, Barber DL. Nelson CE, et al. Among authors: via le. Sci Immunol. 2022 Mar 10:eabo0535. doi: 10.1126/sciimmunol.abo0535. Online ahead of print. Sci Immunol. 2022. PMID: 35271298 Free PMC article.
Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography.
Via LE, Schimel D, Weiner DM, Dartois V, Dayao E, Cai Y, Yoon YS, Dreher MR, Kastenmayer RJ, Laymon CM, Carny JE, Flynn JL, Herscovitch P, Barry CE 3rd. Via LE, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4391-402. doi: 10.1128/AAC.00531-12. Epub 2012 Jun 11. Antimicrob Agents Chemother. 2012. PMID: 22687508 Free PMC article.
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk.
Mayer-Barber KD, Andrade BB, Oland SD, Amaral EP, Barber DL, Gonzales J, Derrick SC, Shi R, Kumar NP, Wei W, Yuan X, Zhang G, Cai Y, Babu S, Catalfamo M, Salazar AM, Via LE, Barry CE 3rd, Sher A. Mayer-Barber KD, et al. Among authors: via le. Nature. 2014 Jul 3;511(7507):99-103. doi: 10.1038/nature13489. Epub 2014 Jun 25. Nature. 2014. PMID: 24990750 Free PMC article.
Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.
Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE 3rd, Jain RK. Datta M, et al. Among authors: via le. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1827-32. doi: 10.1073/pnas.1424563112. Epub 2015 Jan 26. Proc Natl Acad Sci U S A. 2015. PMID: 25624495 Free PMC article.
The association between sterilizing activity and drug distribution into tuberculosis lesions.
Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Among authors: via le. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.
Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques.
Kauffman KD, Sallin MA, Sakai S, Kamenyeva O, Kabat J, Weiner D, Sutphin M, Schimel D, Via L, Barry CE 3rd, Wilder-Kofie T, Moore I, Moore R, Barber DL. Kauffman KD, et al. Mucosal Immunol. 2018 Mar;11(2):462-473. doi: 10.1038/mi.2017.60. Epub 2017 Jul 26. Mucosal Immunol. 2018. PMID: 28745326 Free PMC article.
Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.
Sarathy JP, Via LE, Weiner D, Blanc L, Boshoff H, Eugenin EA, Barry CE 3rd, Dartois VA. Sarathy JP, et al. Among authors: via le. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e02266-17. doi: 10.1128/AAC.02266-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29203492 Free PMC article.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE 3rd. Oh S, et al. Among authors: via le. J Med Chem. 2018 Nov 21;61(22):9952-9965. doi: 10.1021/acs.jmedchem.8b00883. Epub 2018 Nov 5. J Med Chem. 2018. PMID: 30350998 Free PMC article.
158 results