Saxton RA - Search Results

1

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.

Glassman CR, Tsutsumi N, Saxton RA, Lupardus PJ, Jude KM, Garcia KC. Glassman CR, et al. Among authors: saxton ra. Science. 2022 Apr 8;376(6589):163-169. doi: 10.1126/science.abn8933. Epub 2022 Mar 10. Science. 2022. PMID: 35271300 Free PMC article.

2

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM. Saxton RA, et al. Science. 2016 Jan 1;351(6268):53-8. doi: 10.1126/science.aad2087. Epub 2015 Nov 19. Science. 2016. PMID: 26586190 Free PMC article.

3

Dimerization quality control ensures neuronal development and survival.

Mena EL, Kjolby RAS, Saxton RA, Werner A, Lew BG, Boyle JM, Harland R, Rape M. Mena EL, et al. Among authors: saxton ra. Science. 2018 Oct 12;362(6411):eaap8236. doi: 10.1126/science.aap8236. Epub 2018 Sep 6. Science. 2018. PMID: 30190310

4

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.

Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC. Mohan K, et al. Among authors: saxton ra. Science. 2019 May 24;364(6442):eaav7532. doi: 10.1126/science.aav7532. Epub 2019 May 23. Science. 2019. PMID: 31123111 Free PMC article.

5

Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.

Saxton RA, Tsutsumi N, Su LL, Abhiraman GC, Mohan K, Henneberg LT, Aduri NG, Gati C, Garcia KC. Saxton RA, et al. Science. 2021 Mar 19;371(6535):eabc8433. doi: 10.1126/science.abc8433. Science. 2021. PMID: 33737461 Free PMC article.

6

The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.

Saxton RA, Henneberg LT, Calafiore M, Su L, Jude KM, Hanash AM, Garcia KC. Saxton RA, et al. Immunity. 2021 Apr 13;54(4):660-672.e9. doi: 10.1016/j.immuni.2021.03.008. Immunity. 2021. PMID: 33852830 Free PMC article.

7

Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering.

Saxton RA, Garcia KC. Saxton RA, et al. FEBS J. 2022 Dec;289(24):8032-8036. doi: 10.1111/febs.16207. Epub 2021 Sep 29. FEBS J. 2022. PMID: 34543517 Free PMC article. Review.

8

Emerging principles of cytokine pharmacology and therapeutics.

Saxton RA, Glassman CR, Garcia KC. Saxton RA, et al. Nat Rev Drug Discov. 2023 Jan;22(1):21-37. doi: 10.1038/s41573-022-00557-6. Epub 2022 Sep 21. Nat Rev Drug Discov. 2023. PMID: 36131080 Free PMC article. Review.

9

Structural basis of Janus kinase trans-activation.

Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC. Caveney NA, et al. Among authors: saxton ra. Cell Rep. 2023 Mar 28;42(3):112201. doi: 10.1016/j.celrep.2023.112201. Epub 2023 Mar 2. Cell Rep. 2023. PMID: 36867534 Free PMC article.

10

Structural insights into the mechanism of leptin receptor activation.

Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC. Saxton RA, et al. Nat Commun. 2023 Mar 31;14(1):1797. doi: 10.1038/s41467-023-37169-6. Nat Commun. 2023. PMID: 37002197 Free PMC article.

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