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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S. Ye L, et al. Among authors: clark p. Cell Metab. 2022 Apr 5;34(4):595-614.e14. doi: 10.1016/j.cmet.2022.02.009. Epub 2022 Mar 10. Cell Metab. 2022. PMID: 35276062 Free PMC article.
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.
Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Peng L, et al. Among authors: clark p. Nat Commun. 2022 Mar 28;13(1):1638. doi: 10.1038/s41467-022-29288-3. Nat Commun. 2022. PMID: 35347138 Free PMC article.
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Fang Z, et al. Among authors: clark p. Nat Commun. 2022 Jun 6;13(1):3250. doi: 10.1038/s41467-022-30878-4. Nat Commun. 2022. PMID: 35668119 Free PMC article.
Massively parallel knock-in engineering of human T cells.
Dai X, Park JJ, Du Y, Na Z, Lam SZ, Chow RD, Renauer PA, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Dai X, et al. Among authors: clark p. Nat Biotechnol. 2023 Sep;41(9):1239-1255. doi: 10.1038/s41587-022-01639-x. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702900 Free PMC article.
3,005 results