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Page 1
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Fernández-Pisonero I, Clavaín L, Robles-Valero J, Lorenzo-Martín LF, Caloto R, Nieto B, García-Macías C, Oeste CL, Sánchez-Martín M, Abad A, Hortal A, Caballero D, González M, Dosil M, Alarcón B, Bustelo XR. Fernández-Pisonero I, et al. Among authors: clavain l. Cell Rep. 2022 Mar 15;38(11):110522. doi: 10.1016/j.celrep.2022.110522. Cell Rep. 2022. PMID: 35294890 Free article.
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Hortal AM, Oeste CL, Cifuentes C, Alcoceba M, Fernández-Pisonero I, Clavaín L, Tercero R, Mendoza P, Domínguez V, García-Flores M, Pintado B, Abia D, García-Macías C, Navarro-Bailón A, Bustelo XR, González M, Alarcón B. Hortal AM, et al. Among authors: clavain l. Mol Cancer. 2022 Feb 4;21(1):35. doi: 10.1186/s12943-022-01496-x. Mol Cancer. 2022. PMID: 35120522 Free PMC article.
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Clavaín L, Fernández-Pisonero I, Movilla N, Lorenzo-Martín LF, Nieto B, Abad A, García-Navas R, Llorente-González C, Sánchez-Martín M, Vicente-Manzanares M, Santos E, Alarcón B, García-Aznar JM, Dosil M, Bustelo XR. Clavaín L, et al. Oncogene. 2023 Jan;42(5):389-405. doi: 10.1038/s41388-022-02563-9. Epub 2022 Dec 7. Oncogene. 2023. PMID: 36476833 Free PMC article.
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH. Mihaylova MM, et al. Among authors: clavain l. Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001. Cell Stem Cell. 2018. PMID: 29727683 Free PMC article.