DeFea K - Search Results

1

In vivo and in vitro Characterization of a Partial Mu Opioid Receptor Agonist, NKTR-181, Supports Future Therapeutic Development.

Lee AS, Tiwari S, Bishop I, Matossian V, Romaneschi N, Miyazaki T, VanderVeen L, Zalevsky J, DeFea K, Cahill CM, Walwyn WM. Lee AS, et al. Among authors: defea k. Front Pain Res (Lausanne). 2021 Aug 23;2:695962. doi: 10.3389/fpain.2021.695962. eCollection 2021. Front Pain Res (Lausanne). 2021. PMID: 35295409 Free PMC article.

2

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. DeFea KA, et al. J Cell Biol. 2000 Mar 20;148(6):1267-81. doi: 10.1083/jcb.148.6.1267. J Cell Biol. 2000. PMID: 10725339 Free PMC article.

3

Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway.

Mittal N, Roberts K, Pal K, Bentolila LA, Fultz E, Minasyan A, Cahill C, Pradhan A, Conner D, DeFea K, Evans C, Walwyn W. Mittal N, et al. Among authors: defea k. Cell Rep. 2013 Nov 27;5(4):1010-21. doi: 10.1016/j.celrep.2013.10.015. Epub 2013 Nov 14. Cell Rep. 2013. PMID: 24239352 Free PMC article.

4

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy.

John S, Walwyn DR, DeFea K, Hales TG, Walwyn W. John S, et al. Among authors: defea k. Front Pharmacol. 2023 Jul 14;14:1251958. doi: 10.3389/fphar.2023.1251958. eCollection 2023. Front Pharmacol. 2023. PMID: 37521481 Free PMC article. No abstract available.

5

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.

DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Déry O, Bunnett NW. DeFea KA, et al. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11086-91. doi: 10.1073/pnas.190276697. Proc Natl Acad Sci U S A. 2000. PMID: 10995467 Free PMC article.

6

Protein kinase C-mediated desensitization of the neurokinin 1 receptor.

Déry O, Defea KA, Bunnett NW. Déry O, et al. Among authors: defea ka. Am J Physiol Cell Physiol. 2001 May;280(5):C1097-106. doi: 10.1152/ajpcell.2001.280.5.C1097. Am J Physiol Cell Physiol. 2001. PMID: 11287322 Free article.

7

A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis.

Ge L, Ly Y, Hollenberg M, DeFea K. Ge L, et al. Among authors: defea k. J Biol Chem. 2003 Sep 5;278(36):34418-26. doi: 10.1074/jbc.M300573200. Epub 2003 Jun 23. J Biol Chem. 2003. PMID: 12821670 Free article.

8

Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

Kumar P, Lau CS, Mathur M, Wang P, DeFea KA. Kumar P, et al. Among authors: defea ka. Am J Physiol Cell Physiol. 2007 Jul;293(1):C346-57. doi: 10.1152/ajpcell.00010.2007. Epub 2007 Apr 18. Am J Physiol Cell Physiol. 2007. PMID: 17442737 Free article.

9

Beta-arrestin multimers: does a crowd help or hinder function?

DeFea KA. DeFea KA. Biochem J. 2008 Jul 1;413(1):e1-3. doi: 10.1042/BJ20081009. Biochem J. 2008. PMID: 18537791

10

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.

Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA. Wang P, et al. BMC Biochem. 2010 Sep 21;11:36. doi: 10.1186/1471-2091-11-36. BMC Biochem. 2010. PMID: 20858278 Free PMC article.

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