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Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells.
Uchenunu O, Zhdanov AV, Hutton P, Jovanovic P, Wang Y, Andreev DE, Hulea L, Papadopoli DJ, Avizonis D, Baranov PV, Pollak MN, Papkovsky DB, Topisirovic I. Uchenunu O, et al. Among authors: zhdanov av. FEBS Open Bio. 2022 May;12(5):959-982. doi: 10.1002/2211-5463.13398. Epub 2022 Apr 1. FEBS Open Bio. 2022. PMID: 35302710 Free PMC article.
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.
O'Hagan KA, Cocchiglia S, Zhdanov AV, Tambuwala MM, Cummins EP, Monfared M, Agbor TA, Garvey JF, Papkovsky DB, Taylor CT, Allan BB. O'Hagan KA, et al. Among authors: zhdanov av. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2188-93. doi: 10.1073/pnas.0808801106. Epub 2009 Jan 28. Proc Natl Acad Sci U S A. 2009. PMID: 19179292 Free PMC article.
82 results