Sippl W - Search Results

1

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.

Zeyen P, Zeyn Y, Herp D, Mahmoudi F, Yesiloglu TZ, Erdmann F, Schmidt M, Robaa D, Romier C, Ridinger J, Herbst-Gervasoni CJ, Christianson DW, Oehme I, Jung M, Krämer OH, Sippl W. Zeyen P, et al. Among authors: sippl w. Eur J Med Chem. 2022 Apr 15;234:114272. doi: 10.1016/j.ejmech.2022.114272. Epub 2022 Mar 11. Eur J Med Chem. 2022. PMID: 35306288 Free PMC article.

2

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.

Trapp J, Jochum A, Meier R, Saunders L, Marshall B, Kunick C, Verdin E, Goekjian P, Sippl W, Jung M. Trapp J, et al. Among authors: sippl w. J Med Chem. 2006 Dec 14;49(25):7307-16. doi: 10.1021/jm060118b. J Med Chem. 2006. PMID: 17149860

3

Target-based approach to inhibitors of histone arginine methyltransferases.

Spannhoff A, Heinke R, Bauer I, Trojer P, Metzger E, Gust R, Schüle R, Brosch G, Sippl W, Jung M. Spannhoff A, et al. Among authors: sippl w. J Med Chem. 2007 May 17;50(10):2319-25. doi: 10.1021/jm061250e. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432842

4

A novel arginine methyltransferase inhibitor with cellular activity.

Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schüle R, Hanefeld W, Sippl W, Jung M. Spannhoff A, et al. Among authors: sippl w. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4150-3. doi: 10.1016/j.bmcl.2007.05.088. Epub 2007 Jun 3. Bioorg Med Chem Lett. 2007. PMID: 17570663

5

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).

Trapp J, Meier R, Hongwiset D, Kassack MU, Sippl W, Jung M. Trapp J, et al. Among authors: sippl w. ChemMedChem. 2007 Oct;2(10):1419-31. doi: 10.1002/cmdc.200700003. ChemMedChem. 2007. PMID: 17628866

6

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).

Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M. Schäfer S, et al. Among authors: sippl w. Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. doi: 10.1016/j.bmc.2007.10.092. Epub 2007 Nov 4. Bioorg Med Chem. 2008. PMID: 18054239

7

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.

Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, Verdin E, Sippl W, Jung M. Neugebauer RC, et al. Among authors: sippl w. J Med Chem. 2008 Mar 13;51(5):1203-13. doi: 10.1021/jm700972e. Epub 2008 Feb 13. J Med Chem. 2008. PMID: 18269226

8

Inhibitors of NAD+ dependent histone deacetylases (sirtuins).

Neugebauer RC, Sippl W, Jung M. Neugebauer RC, et al. Among authors: sippl w. Curr Pharm Des. 2008;14(6):562-73. doi: 10.2174/138161208783885380. Curr Pharm Des. 2008. PMID: 18336301 Review.

9

Cancer treatment of the future: inhibitors of histone methyltransferases.

Spannhoff A, Sippl W, Jung M. Spannhoff A, et al. Among authors: sippl w. Int J Biochem Cell Biol. 2009 Jan;41(1):4-11. doi: 10.1016/j.biocel.2008.07.024. Epub 2008 Aug 14. Int J Biochem Cell Biol. 2009. PMID: 18773966 Review.

10

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.

Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, Sippl W. Uciechowska U, et al. Among authors: sippl w. ChemMedChem. 2008 Dec;3(12):1965-76. doi: 10.1002/cmdc.200800104. ChemMedChem. 2008. PMID: 18985648

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